A mitochondrial #EglN1/#PHD2-#AMPK-alpha axis drives #breastcancer progression by enhancing metabolic adaptation to #hypoxic stress

#Hypoxia-induced EglN1-#CaMKK2 interaction on #mitochondrial safeguards AMPKα activation and #metabolic homeostasis during breast cancer growth

https://www.embopress.org/doi/full/10.15252/embj.2023113743

Article highlighting a new paper in #GreatLakes Research on links between #algalblooms and #hypoxia. Low oxygen in the Central Basin is an important impairment to the #LakeErie ecosystem that will be a focus of the 🇨🇦🇺🇸 Cooperative Science and Monitoring Initiative #CSMI next year. We are in the midst planning many projects to target #geochemistry, #nutrients, #foodwebs and habitat use during the 2024 fieldyear.
#Canada #USA #ClimateChange
https://windsor.ctvnews.ca/more-algal-blooms-likely-in-lake-erie-report-1.6493160

A very nice day 😎 today for some #collaborative #science on the Fisheries and Oceans Canada (#DFO) R.V. Cisco within #Hamilton Harbour. The team from #SUNY Buffalo State is out collecting benthos with Ponar sampler and drop-down camera (Benthic Imaging System) to complement our monitoring project looking at zooplankton and phytoplankton in the Harbour, which is impacted by #Hypoxia (low or no oxygen) during the summer. #GreatLakes

Can #hypoxia extend a healthy lifespan? This #PLOSBiology study reveals that oxygen restriction can extend lifespan and counter neurological demise in a mouse model of accelerated #aging.
https://plos.io/3owJHA3

Can #hypoxia extend a healthy lifespan? This #PLOSBiology study reveals that oxygen restriction can extend lifespan and counter neurological demise in a mouse model of accelerated #aging.
https://plos.io/3owJHA3

Finding Nemo. A new study shows that #anemonefish larvae exhibit physiological & transcriptomic changes associated with swimming, O2 uptake & #hypoxia tolerance, potentially aiding dispersal of the pelagic larval phase #PLOSBiology #marinebiology https://plos.io/3pAU9qg

#Glutamate dehydrogenase1 supports #HIF1α stability to promote #colorectal #tumorigenesis under #hypoxia

An siRNA screen identifies αKG metabolic enzyme #GDH1 as acetylation-dependent control factor for intestinal cancer progression

https://www.embopress.org/doi/10.15252/embj.2022112675

https://umem.org/educational_pearls/4141/

This week’s pearl reminds us to avoid hypoxia and hypotension in traumatically brain injured patients. #trauma #tbi #hypoxia #annalsofEM #pre-oxygenate

Projected #ocean #warming and #deoxygenation will increase the duration, intensity and severity of #hypoxia, with >94% & 31% of #reefs experiencing weak to moderate and severe hypoxia, respectively, by 2100 under Shared Socioeconomic Pathways 5-8.5.

#climatechange
https://www.nature.com/articles/s41558-023-01619-2?utm_source=twitter&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_NATUREPORTFOLIO

#CardioMastodon @JACCJournals A 1-day-old girl with #Hypoxia but no respiratory distress. #EchoFirst ➡️ isolated ventricular inversion, which is extremely rare (<20 #CaseReports)
📌 https://www.jacc.org/doi/10.1016/j.jaccas.2022.09.012?utm_medium=social&utm_source=twitter_post&utm_campaign=twitter_post
📌 https://www.jacc.org/toc/case-reports/current
📌 https://www.jacc.org/journal/case-reports

Li-Juan Duan et al. show that #Tailless (TLX) and #hypoxia inducible factor-2α (HIF2α) cooperate to sustain proangiogenic states of retinal #astrocytes in neonatal mice:

https://journals.biologists.com/bio/article/12/1/bio059684/286421/Tailless-and-hypoxia-inducible-factor-2-cooperate

#Retina #Angiogenesis #OxygenSensing #Science #BiologyOpen #Biology #AcademicMastodon

RT @hudsonwilco: Our new study is out in @eLife! We discovered that a key #cholesterol synthesis enzyme becomes constitutively activated during #hypoxia, helping to maintain flux through the pathway. @BrownLabUNSW @UNSWBABS @UNSWScience

https://elifesciences.org/articles/82843

(1/10)

Cause #Hypoxia is EVERYWHERE during dying. And it would not be hard to strongly suggest that undertreated hypoxia played a role in a lot of deaths.

RT MicroSensing: We are looking for a #postdoc to join #FutureReefs lab \@uts_c3 in a new ARC funded project on #hypoxia / #deoxygenation effects on #corals. Exciting collaborative project \@emmafcamp \@reefgenomics \@MicroSensing \@DrCarlyRandall \@DavidJSuggett

QT DavidJSuggett: Postdoc Opp (upto 3yr) to join #FutureReefs lab \@uts_c3 in collaboration with \@MicroSensing \@reefgenomics \@DrCarlyRandall as part of new ARC Discovery… https://twitter.com/twitter/status/1603653771464155136

Peter Horby “RECOVERY pre-print out.
In hypoxic hospitalised COVID-19 patients requiring either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared to usual care, which included low dose corticosteroids.”
#COVID19
#Dexamethasone
#RECOVERY
#Hypoxia
#LowDoseIsBetter

https://www.medrxiv.org/content/10.1101/2022.12.16.22283578v1

His thread at https://twitter.com/peterhorby/status/1604774719294619648?s=46&t=c-yh5b05N5xtYA50a31Bbw

Adenosine is a molecule that plays a role in many different biological processes. It is involved in the #hyperaemic response, which is when the blood flow to the #myocardium (heart muscle) increases in response to #hypoxia or ischemia (lack of oxygen). Adenosine is also involved in #bone remodelling, where it can activate certain receptors to either increase or decrease the development of #osteoclasts (cells that break down bone).

Featured in issue 23 of our anniversary year:
How delayed folding aids #protein secretion

Plant and mammalian #ubiquitin E3 #ligases against #bacterial #infection
#CryoEM glimpses at membrane pore formation and #ion transporters
#Autophagosomes in need of balanced #phospholipid composition
#Hypoxia promotes #osteogenesis by facilitating #mitochondria to
#nucleus communication

Cover by by Subhash Mehto, Kautilya Kumar Jena, Santosh Chauhan et al
https://www.embopress.org/toc/14602075/2022/41/23

This is the era of SARS caused sudden deaths. Welcome to hell. Soon i will be dead too. Many of us will. Society still won't care. Life itself became worthless and expandable. What have we done? What have we become? All the videos of Wuhan 2020 are now global scale day to day reality. So many sudden deaths, weird "accidents". Pilots dying midair. Yet people don't connect the dots. #SarsCoV2 #SuddenDeath #LongCovid #PostVac #POTS #Stroke #CardiacArrest #Hypoxia

#NewPaper -- we use #ExperimentalEvolution to show:
-- gaining a tetracycline efflux pump by HGT is super costly for Staph aureus in low oxygen environments
-- treatment with tetracyclines prevents evolutionary adaptation to low oxygen (via gyrB mutation)

Possibly explains why tetracyclines remain useful treatments for Staph aureus infections that are often characterised by #hypoxia

Led by amazing PhD student Rebecca Hull

#Staphylococcusaureus #AMR #antibiotics

https://journals.asm.org/eprint/N8RXMPWTFJWVHZUAN55G/full

Dear followers, I just moved my account to this new address!
I am a #scientist using #models of #ocean #bioGeoChemistry to study the effects of #acidification, #hypoxia, and #climateChange on #vulnerable #organisms like #pteropods. I am also a #musician and play #clawhammer #banjo and #guitar. Thanks for following!!