#IDMastodon #PublicHealth @conversationuk
#influenza is a seasonal virus that emerges and peaks in winter, so with evenings shortening in 🇬🇧 it’s time to think about #fluvaccine .Countries in the northern hemisphere closely monitor flu trends in 🇦🇺 …
https://theconversation.com/flu-season-started-early-in-australia-countries-in-the-northern-hemisphere-took-note-207967?utm_source=twitter&utm_medium=bylinetwitterbutton

#IDMastodon Analysis of the association between the new #SARSCoV2 variant EG.5 /‘#Eris’ & XBB #breakthroughinfection .BTI of XBB subvariants cannot efficiently induce antiviral #humoralimmunity against the infecting variants vs the BTI of previous #omicronvariants. clarification the characteristics of EG.5 (Eris) which is becoming increasingly prevalent around 🌎

#IDMastodon #PedsICU @jci_insight Characterization of maternal & fetal responses during gestational #SARSCoV2 infection. upon #SARSCoV2 infection, pregnant women mount an inflammatory response composed of IFN-α, IL-6, IL-10, IL-18, IL-33 & MCP-1. Intriguingly, cytokines related to acute viral response returned to normal levels upon infection clearance,

#IDMastodon #Immunopharmacology Drugs #Adverseeffetcs #remdesivir appeared to have a small mortality benefit in #COVID19 hospitalized patients who were not already being ventilated at baseline. Remdesivir was generally well tolerated in #clinicaltrials

#IDMastodon #Cellular & #MolecularImmunology The more I learned about the nature of #COVID & the more ‘I ‘m lost for words ’ This 🦠 is nasty & sophisticated than anykind ..😷💉is one step ahead the crowd . A high infection rate by #SarsCoV2 may lead to exaggerated #cytokine responses, which may contribute to tissue damage & severe disease.
#Macrophage #phagocytosis of #SARSCoV2-infected cells mediates potent #plasmacytoiddendriticcell activation
https://www.nature.com/articles/s41423-023-01039-4

#IDMastodon #Immunopharmacology #Pleuralinfection is usually treated with empirical broad-spectrum antibiotics but limited data exists around their penetrance into the infected pleural space.
What’s #Fleuralinfection
https://www.sciencedirect.com/topics/medicine-and-dentistry/pleural-infection#:~:text=Pleural%20infection%20commonly%20presents%20with,the%20diagnosis%20is%20often%20unsuspected.

#IDMastodon MedSky🧪Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, & Respiratory Symptom Clusters Following Symptomatic #COVID19 . Excellent & useful Highlights from @jama_current on the global burden of #LongCovid , #morphine for breathlessness in #COPD & #autotaxininhibitor treatment for #idiopathicpulmonaryfibrosis

https://subscriptions.jamanetwork.com/ers/wp-content/uploads/sites/7/2023/08/ERS-2023-JAMA-session-booklet.pdf

#IDMastodon @bmj_latest Some 1.9 MiL people in 🇬🇧almost 3% of the population were estimated to have #longcovid This March . There is a long list of potential symptoms, with a 🇬🇧 study finding more than 200 across 10 different organ systems .NICE ‘s reported symptoms & Care Pathways
https://www.bmj.com/content/382/bmj.p1791
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00299-6/fulltext

#IDMastodon #NeuroCOVID Four decades of ME/CFS research: what Long COVID researchers can learn. Following up on 31,486 symptomatic infections for 18 months, it was determined that 1856 (6 %) had not recovered & 13,350 (42%) had recovered only partially. ‘PASC’in the RECOVER protocols is ongoing, relapsing, or new symptoms,or other health effects occurring after the acute phase (4- more weeks)of #SARSCoV2 infection & those with persistent symptoms that cannot be explained by major organ injuries

#IDmastodon @northwesternu
That’s great in the Marching of #Eris & #pirola ‘#MaskUp & ’Mind that #viralload #COVID patients exhale up to 1,000 copies of 🦠 per minute during first 8 days of symptoms .First direct measure of #SARSCoV2 viral copies exhaled over the course of infection
https://news.northwestern.edu/stories/2023/09/covid-patients-exhale-up-to-1000-copies-of-virus-per-minute-during-first-eight-days-of-symptoms/

#IDMastodon #CovidIsNotOver #MaskUp 😷 #GetBoosted @gomez_rial
The chronic pro-inflammatory state was associated with #SarsCoV2 infections in unvaccinated individuals during the 1st wave, due to the action of an uncontrolled #innateimmunity. This phenomenon can be avoided with #covid19vaccination. The immune system after infection is perfectly competent in its functions.

#IDMastodon #MolecularMedicine #Viralimmunology Excellent illustration from @virusesimmunity @SheaJAndrews
by @GitaPathakPhD on the genetic susceptibility to acute severe #COVID19 & #SARSCoV2 infection. At One Glance you learn the critical genes involved in The candidate genes are implicated in 3 key pathways: viral entry, mucosal airway defense, & type I interferon signaling..
@Nature
https://www.nature.com/articles/s41586-023-06355-3

#IDMastodon #virology These observations suggest that BA.2.86 is more closely related to sequences from Southern Africa than other regions & so may have evolved there, and that evolution led to escape from #neutralizingantibodies similar in scale to recently circulating strains of #SARSCoV2.
https://www.medrxiv.org/content/10.1101/2023.09.08.23295250v1.full.pdf

One of the things I became aware of in #COVID19 was how #wastewater #surveillance can be such a useful #publichealth tool to monitor emergence and activity of infections in the community.

Great article on this 👇
#IDMastodon #medicine #MedMastodon #AMR #viruses #infectiousdiseases #mpox

Wastewater monitoring: 'the James Webb Telescope for population health' | Exemplars in Global Health https://www.exemplars.health/stories/the-james-webb-telescope-for-population-health

Linezolid probably a bit safer than we think & probably can give >4 weeks with close observation.

Great drug, it's oral, but still makes me a bit apprehensive about using it for a long course, certainly at 600mg BD.

#IDMastodon #MedMastodon #AMR #antibiotics #microbiology #medicine #linezolid

Prolonged use of linezolid in bone and joint infections: a retrospective analysis of adverse effects | Journal of Antimicrobial Chemotherapy | Oxford Academic https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad276/7264092

Reminder to pick your outcomes.

Vancomycin vs Fidaxomicin in #Cdiff- same mortality, but lower recurrence with fidaxo
#Clostridiumdifficile #antibiotics #microbiology #IDMastodon #infectiousdeseases

The Effect of Antibiotic Therapy for Clostridioides difficile Infection on Mortality and Other Patient-Relevant Outcomes: a Systematic Review and Meta-analysis - Clinical Microbiology and Infection https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00420-2/fulltext

👉 #rabies can incubate for a year or more
👉 If risk exposure has occurred, it is never too late to start post-exposure prophylaxis
👉 According to both WHO and CDC guidelines, a decision to vaccinate is a decision to use RIG as the vaccine will not kick in for several weeks
#IDMastodon #MedMastodon #IMPearls #MedEd

#IDMastodon MedSky🧪Dissection of the host immunity from the bones to the fat by #SARSCoV2 infection .HDL levels are reduced in patients with #COVID19 & the extent of this reduction is associated with server COVID19. HDL has been shown to stimulate the cellular uptake of #SARSCoV2 spike protein and promote infection, with the mechanism being deemed to be through cholesterol binding rather than protein–protein interaction.

"This is very surprising. It doesn’t feel like it’s a move that would help solve ProMED’s problems ... The strength of ProMED is not in the technology, it’s in the people ... And if you eliminate the people, you’re not left with much."

Group behind ProMED fires three top moderators amid strike

https://www.statnews.com/2023/09/07/promed-terminates-top-moderators/

#IDMastodon #InfectiousDiseases

#IDMastodon 🧵the results on BA.2.86 - transmissibility, infectivity and immune resistance from @systemsvirology
https://threadreaderapp.com/thread/1699707542589567071.html
New data from @BarouchLab on BA.2.86.
1. NAb responses to BA.2.86 were lower than to BA.2 but were comparable or higher than to current circulating variants.
2. NAb titers to all variants including BA.2.86 increased following XBB infection