Finally, it’s out! I must say, I am really, really fond of this paper– if you are into #innateimmunity, the #antiviralresponse and #interferon, I think you may enjoy reading it:

https://www.life-science-alliance.org/content/6/10/e202302059

Nothing spectacularly new, but very comprehensive characterization of the #RIGI and #IFN pathway!

Exciting #JobOpening for entry level Bioinformatician to join our team team at CIML! You will work with my team and use scRNAseq on intestinal epithelial cells to understand how #IFN modulate tissue repair in the intestine and to develop pipelines to analyze the intestinal #microbiota and its effect on homeostasis.
You will work in the framework of the CB2M core, where #bioinformaticians collaborate and train each other to develop new skills Apply now! Send CV and Motivation letter.

RT @Lo_Zanzi
#WeekendRead! #TheMoreTheMerrier & #InterferonPower! Acetate derived from #microbiota is sensed by GPR43 & facilitates #NLRP3-dependent #MAVS aggregation on #mitochondria thus potentiating #IFN production & protecting against #IAV #influenza @NatureComms http://Doi.org/10.1038/s41467-023-36323-4

RT @Lo_Zanzi
#InterferonPower! R-loops are three-stranded nucleic acid structures formed during transcription. DNA-RNA hybrids in the cytoplasm are recognized by cGAS & TLR3 & induce IRF3 & #IFN signaling to sustain #autoimmunity, #neurodegeneration & #cancer! @Nature http://doi.org/10.1038/s41586-022-05545-9

@fitterhappierAJ @whn

RT @casanova_lab

12/ Interestingly, while #inborn errors or auto-Abs that impair type I #IFN activity underlie critical #COVID-19 €pneumonia (science.org/doi/10.1126/sc…, science.org/doi/10.1126/sc…), the deficiency of this single type I IFN-inducible #pathway does not – on the contrary, it underlies #MIS-C

https://www.science.org/doi/10.1126/science.abd4570

RT @LoweLabMSKCC@twitter.com

Now out in @NatureCancer@twitter.com, an updated version of our study developing the #MACHETE strategy for modeling large genomic deletions and using it to uncover a key role for type I #IFN deletions in tumor #ImmuneEvasion & #Metastasis: https://www.nature.com/articles/s43018-022-00443-5 (1/3) https://twitter.com/LoweLabMSKCC/status/1562126471845629953

🐦🔗: https://twitter.com/LoweLabMSKCC/status/1589653132568858625