Secukinumab blocks IL-17 and some evidence of efficacy in hidradenitis suppurativa in 2x RCT.

Interesting in so much this is clearly an inflammatory disease in which there is also undoubtedly an infective component.

These studies, along with efficacy of TNF blockade indicates hyperinflammation the main issue.

#immunology #inflammation #hidradenitis #IL17 #secukinumab #RCT #trial #hyperinflammation

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00022-3/fulltext?dgcid=raven_jbs_aip_email

FOLLOW @RepEricSorensen@twitter.com

RT @RepRobertGarcia@twitter.com

.@RepEricSorensen@twitter.com worked as a chief meteorologist, a community leader, and local educator. He now represents #IL17 as the first openly gay LGBTQI+ person elected to Congress from Illinois. I look forward to working with Rep. Sorensen as he leads the fight to protect our climate.

🐦🔗: https://twitter.com/RepRobertGarcia/status/1615778873198927873

RT Paul Ogongo
Our latest work show #IL17 #CD4 #Tcells are preserved in HIV-ART. We identify two subsets of #Th17 cells; 1 specifically enriched for IL17 production to #Mtb but not CMV or SEB; and link between IDO-1 activity and circulating Th17 cells.@AnthonyVanTran @UCSF_EXPM @UCSF_GIVI_CFAR

M. tuberculosis antigen-responsive IL17+ CD4 T cells are disproportionately spared in ART-suppressed HIV biorxiv.org/cgi/content/sh… #biorxiv_immuno

The appetite for trying to understand the balance between protection and pathology offered by IL-17 continues to grow...
#immunology #IL17 #MedMastodon
@NatRevImmunol https://www.nature.com/articles/s41577-022-00746-9?utm_source=nri_etoc&utm_medium=email&utm_campaign=toc_41577_23_1&utm_content=20230106

You guys can have Maxwell Frost, this is my favorite freshman Rep right here.
#IL17

RT @ERICSORENSEN@twitter.com

It’s easier making a forecast for the location of the rain/snow line during a bomb cyclone under a 300 millibar jet streak 13 days from now than understanding when Republicans will settle on a Speaker. #ChiefMeteorologistInCongress #118thCongress #HouseSpeaker #LetsGetToWork

🐦🔗: https://twitter.com/ERICSORENSEN/status/1610850040578461697

Nice study showing Candida albicans lipase suppressing host IL-17 responses & promotes invasive infection.

Caveats re model systems used, etc.. but interesting demonstration of pathogen evasion of protective host immune responses.
#mycology #immunology #IDMastodon #Science #IL17 #Candida

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00517-0#secsectitle0070

A meteorologist in Congress.
It’s a beautiful day.
#IL17’s @ERICSORENSEN@twitter.com is gonna be an exciting Rep to follow…

RT @TeamPelosi@twitter.com

Democratic Victory: Congratulations to Congressman-Elect Eric Sorensen @ERICSORENSEN@twitter.com on your election in #IL17! -NP

🐦🔗: https://twitter.com/TeamPelosi/status/1590795399232917504

Sure looks good @ERICSORENSEN@twitter.com
#IL17 #climatehawks

Congratulations to climate hawk meteorologist @ERICSORENSEN@twitter.com for winning #IL17 to succeed the retiring @CheriBustos@twitter.com! See you soon in DC!

While my county has turned Red in recent elections, I am grateful that my U.S. House District has stayed In Democratic hands! #IL17

Congrats to @ERICSORENSEN@twitter.com, making history as for gay House member from Illinois. Great having you my show.

RT @ERICSORENSEN@twitter.com

This one's for you #IL17

🐦🔗: https://twitter.com/ERICSORENSEN/status/1590358605639081993

cc: @SimonWDC@twitter.com

RT @brent_peabody@twitter.com

PROJECTION: Eric Sorensen (D) wins #IL17

He's just ahead by 2, but almost all the outstanding vote is in the liberal strongholds of Peoria, Bloomington, and Rockford

Rs were feeling confident about this

DEM HOLD

🐦🔗: https://twitter.com/brent_peabody/status/1590198311533031425

RT @Redistrict@twitter.com

ICYMI, here's the hypothetical 14D-3R gerrymander of Illinois that eliminates Kinzinger's current district. 14/17 seats would be Biden +14 or more - except #IL17, which would zoom from Trump +1.6 to Biden +6.2.

🐦🔗: https://twitter.com/Redistrict/status/1420860021282418690