"The human MPYS gene is highly heterogeneous (9, 10). Approximately 50% of Americans carry a non–wild-type (WT) (R232) MPYS allele (9). R71H-G230A-R293Q (HAQ) is the second most common human MPYS allele carried by ∼25% of Americans and ∼63% of East Asians (EAS) (9). Surprisingly, we recently found that HAQ knock-in mice do not respond to CDNs in vivo (11). In corroboration, Mogensen and colleagues (12) reported that homozygous HAQ MPYS/STING was enriched in HIV-infected individuals that were long-term nonprogressors."

#Immunology #Immunogenetics #JournalImmunology

https://journals.aai.org/jimmunol/article/209/11/2114/237342/MPYS-Modulates-Fatty-Acid-Metabolism-and-Immune

Hello👋 I’m a research fellow and psychiatrist at the University of Cambridge. I work on interactions between the immune system, brain and behaviour esp using #ImmunoGenetics approaches. Interested in #biomarker discovery in psychiatry. Looking forward to discussions on here! #genomics #immunopsychiatry #neuroscience #neuroimmunology #introduction