"Vaccines that resulted in speedy delivery of antigens to follicles preserved intact antigen and generated better antibody responses. These findings may have implications for the design of vaccines against difficult to neutralize or genetically variable pathogens"

#Immunology #ImmunologicalMemory #Antibody #GerminalCenter #Bcells #Vaccine

https://www.science.org/doi/10.1126/science.abn8934

"Three years into the pandemic, the immune systems of the vast majority of humans have learnt to recognize SARS-CoV-2 through vaccination, infection or, in many cases, both. But just how quickly do these types of immunity fade?"

#Immunology #ImmunologicalMemory #COVID19 #COVID #vaccine

https://www.nature.com/articles/d41586-023-00124-y

"We found that TCR signal intensity coupled STING signal strength to the unfolded protein response (UPR) and T cell survival. Under strong STING signaling, Indoleamine-pyrrole 2,3-dioxygenase (IDO) inhibition also reduced apoptosis and led to a recovery of T cell memory in STING sufficient CD8 T cells."

#Immunology #STING #Tcells
#ImmunologicalMemory

https://www.pnas.org/doi/10.1073/pnas.2205049120