Stephen Matheson🌵🌲 · @sfmatheson
714 followers · 726 posts · Server fediscience.orgso, systematically identified conserved, spatially organized anti-tumor immune hubs in solid tumors, associated with #immunotherapy response
many other gene programs still to be explored in anti-tumor hubs
also other hubs such as an #inflammatory hub
now characterizing hubs using MERFISH
next steps to build mouse and organoid models to perturb hubs systematically
2/2
Noodlemaz · @noodlemaz
406 followers · 3046 posts · Server med-mastodon.comWe're about to move house but I bought a #science book about #immunotherapy (bc I'm writing/talking about it a lot so I should know what I'm on about really)
Oops?
#bookstodon
#Science #Immunotherapy #bookstodon
Noodlemaz · @noodlemaz
397 followers · 2767 posts · Server med-mastodon.com
@haritulsidas So, going to the university site and the actual paper https://www.nature.com/articles/s41388-022-02429-0
- what this is is a drug screen. In cells in the lab (in vitro), not in people (some mouse experiments). Also, it's specific to one of the >6 types of #BreastCancer (TNBC), not BC or #cancer generally.
Interesting, and a good start, but it's not a 'breakthrough' as such. Drug screens return promising hits all the time!
#cancerResearch (the #immunotherapy part is super interesting too).
#cancer #breastcancer #cancerresearch #Immunotherapy
Alan Kotok · @technewslit
1014 followers · 541 posts · Server journa.hostA clinical trial assessing a synthetic antibody to generate an immediate response and also generate a more durable treatment for solid tumor cancers, advanced to a mid-stage study.
https://sciencebusiness.technewslit.com/?p=45068
#News #Press #Science #Business #Cancer #Biotechnology #ClinicalTrial #Immunotherapy #AdverseEffects #CheckpointInhibitor #Antibody #ImmuneSystem #TCells #InnateImmuneSystem
#News #press #science #business #cancer #biotechnology #ClinicalTrial #Immunotherapy #adverseeffects #checkpointinhibitor #antibody #immunesystem #Tcells #innateimmunesystem
Alan Kotok · @technewslit
990 followers · 508 posts · Server journa.hostA biotechnology company designing immunotherapies for solid tumor cancers with a patient's white blood cells is raising $80 million in its initial public offering or IPO.
https://sciencebusiness.technewslit.com/?p=45015
#News #Press #Science #Business #Biotechnology #Cancer #SolidTumor #Finance #Immunotherapy TCells #ClinicalTrial #Lymphocytes #Investment #IPO #ImmuneSystem #Licensing #VentureCapital
#News #press #science #business #biotechnology #cancer #solidtumor #finance #Immunotherapy #ClinicalTrial #lymphocytes #investment #IPO #immunesystem #licensing #venturecapital
Alan Kotok · @technewslit
982 followers · 501 posts · Server journa.host
Trial Underway Testing Engineered Cancer-Killing Viruses
A clinical trial, testing stem cells for neurons fortified with tumor-killing viruses, administered its first doses to a patient with glioma, an aggressive type of brain cancer.
https://sciencebusiness.technewslit.com/?p=45004
#News #Press #Science #Business #Cancer #ClinicalTrial #Gliomas #Glioblastoma #BrainTumor #Biotechnology #Adenovirus #Immunotherapy #Onoclytic #Neurons #StemCells #GrantFunding
#News #press #science #business #cancer #ClinicalTrial #gliomas #glioblastoma #BrainTumor #biotechnology #adenovirus #Immunotherapy #onoclytic #neurons #stemcells #grantfunding
halama_immuno · @halama_immuno
329 followers · 1722 posts · Server mstdn.science
#cytokines as #biomarkers for therapeutic success in #NSCLC #nsclctrial #Immunotherapy #pd1 #pdl1 utilizing #MachineLearming , link to downloadable PDF https://bit.ly/3NTxfTt
#cytokines #biomarkers #NSCLC #nsclctrial #Immunotherapy #pd1 #pdl1 #MachineLearming
Gabriele Pollara · @gpollara
915 followers · 2801 posts · Server med-mastodon.comMore host-directed therapy promise in tuberculosis
#TNF #HDT #immunotherapy #immunology #TB #tuberculosis #Science #medicine #MedMastodon #IDMastodon #CNS #meningitis
#TNF #hdt #Immunotherapy #immunology #tb #tuberculosis #Science #medicine #MedMastodon #IDMastodon #cns #meningitis
halama_immuno · @halama_immuno
318 followers · 1685 posts · Server mstdn.scienceThe Helmholtz Institute for Translational Oncology #HI-TRON is looking for a) a motivated master student for the establishment of a novel technology to identify reactive T cells and b) a motivated intern (8 weeks) to broaden the technology of gene delivery. #immunotherapy #immunology #tcellbiology #oncology Please contact through the website https://hi-tron.dkfz.de/
#hi #Immunotherapy #immunology #tcellbiology #oncology
halama_immuno · @halama_immuno
306 followers · 1662 posts · Server mstdn.science
Groundbreaking ceremony for the new building of the Helmholtz Institute for Translational Oncology #HI-TRON in Mainz (Germany), providing a space for novel cutting-edge #immunotherapy development, #personalizedmedicines and #mRNAs as tools in #cancer #research @mainz_de @unimainz @helmholtz @hereon @dkfz
https://www.dkfz.de/de/presse/pressemitteilungen/2023/dkfz-pm-23-33a-HI-TRON-Mainz-ein-Helmholtz-Institut-des-DKFZ-erhaelt-neues-Gebaeude.php
#hi #Immunotherapy #personalizedmedicines #mRNAs #cancer #research
David Basanta Gutierrez · @david
227 followers · 346 posts · Server fediscience.org#Immunoediting and #immunotherapy explained by Kurzgesagt: https://youtu.be/uoJwt9l-XhQ
Video created with the help of my #MoffittCancerCenter colleague Kim Luddy
#MoffittCancerCenter #Immunotherapy #immunoediting
halama_immuno · @halama_immuno
293 followers · 1523 posts · Server mstdn.science#pancreaticcancer is a deadly disease. New #trial data shows early benefits for addition of a personalized #mRNA #vaccine to #adjuvantchemotherapy after resection of the tumor. This feature in Deutsche Welle discusses the implications with Nina Bhardwaj and Drew Weissman #Immunotherapy #oncology https://t.co/j81AOXjcJS
#pancreaticcancer #Trial #mrna #vaccine #adjuvantchemotherapy #Immunotherapy #oncology
halama_immuno · @halama_immuno
290 followers · 1475 posts · Server mstdn.scienceRare #cancer treated with #Immunotherapy : new data for #sarcoma subtype angiosarcoma, treated with double #checkpointinhibitors and showing clinical effects. But we still need better #biomarkers for #precisionmedicine in #immunology ... @chfloudas @cyrilpedia
https://jitc.bmj.com/content/9/8/e002990
#cancer #Immunotherapy #sarcoma #checkpointinhibitors #biomarkers #precisionmedicine #immunology
halama_immuno · @halama_immuno
290 followers · 1475 posts · Server mstdn.science@statto The approach is being investigated in other solid #cancers like #melanoma or #colorectalcancer as well: reduce tumor burden with surgical resection and then add vaccination to the adjuvant (maximum) treatment...ideally a blueprint for success. Let's see what the trials will show... #immunology #immunotherapy
#cancers #melanoma #colorectalcancer #immunology #Immunotherapy
halama_immuno · @halama_immuno
290 followers · 1475 posts · Server mstdn.science
Alan Kotok · @technewslit
865 followers · 397 posts · Server journa.host
Precision T-Cell Solid Tumor Therapy Trial Underway
A clinical trial has begun testing a treatment for solid #tumor #cancers using engineered T-cells with proteins to attack specific tumor cells, but also avoid healthy cells.
https://sciencebusiness.technewslit.com/?p=44842
#News #Science #Business #ClinicalTrial #Biotechnology #Tcells #Immunotherapy #SolidTumor #PrecisionMedicine #CompanionDiagnostic
#tumor #cancers #News #science #business #ClinicalTrial #biotechnology #Tcells #Immunotherapy #solidtumor #precisionmedicine #companiondiagnostic
Alan Kotok · @technewslit
858 followers · 390 posts · Server journa.host
AI-Designed Cancer Vaccine Shown to Act Against Melanoma
Results of a small clinical trial show most patients with #melanoma receiving a personalized therapeutic #vaccine with an approved #immunotherapy reduced at least some of their #tumors.
https://sciencebusiness.technewslit.com/?p=44832
#News #Science #Business #Biotechnology #Cancer #PrecisionMedicine #Tcells #ArtificialIntelligence #Algorithms #ClinicalTrial #ASCO2023
#melanoma #vaccine #Immunotherapy #tumors #News #science #business #biotechnology #cancer #precisionmedicine #Tcells #artificialintelligence #algorithms #ClinicalTrial #asco2023
halama_immuno · @halama_immuno
265 followers · 1189 posts · Server mstdn.science
Fantastic opening presentation by Samra Turaljic @thecrick@bird.makeup @thecrick on #immunological and molecular landscapes in #melanoma and #RenalCellCarcinoma at the #cimt2023 meeting in Mainz, Germany #HI-TRON #immunology #Immunotherapy
#immunological #melanoma #renalcellcarcinoma #cimt2023 #hi #immunology #Immunotherapy
Sean Gibbons · @gibbological
213 followers · 517 posts · Server mstdn.science
RT @cellhostmicrobe
Fuso induces tumor resistance to #immunotherapy. New work reports that Fusobacterium nucleatum-derived succinic acid diminishes sensitivity to anti-PD-1 mAb in #ColorectalCancer by impairing CD8+ #Tcell-mediated antitumor immunity https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00161-0
#Immunotherapy #colorectalcancer #Tcell
Patrick Mitchell · @psmitchej
113 followers · 73 posts · Server fediscience.org
RT @roose_jeroen
Last call - abstracts!!! @FaseB. Shaping up to be a great conference, judging from registrations that are in. #signaling #immunology #immunotherapy #networking. Great for trainees: travel grants! @barton_lab
@DanBStetson1 @griffiths_lab @RauchLab
@LabDac @MaxKrummel. Please RT. https://twitter.com/FASEBorg/status/1650879342476443651
#networking #Immunotherapy #immunology #signaling