#InMice [with "humanised" ACE2 receptors]

Some paper quotes:

"K18-ACE2 transgenic mice vaccinated with VAANZ-delta_RRN were completely protected from live SARS-CoV-2 intranasal challenge"

"we describe a novel RBD-based protein vaccine (VAANZ-delta_RRN) that is highly immunogenic, expresses well, and has a good stability profile. We showed that the incorporation of an NTD... correlated with improved antibody function."

#InMice [with "humanised" ACE2 receptors]

Some paper quotes:

"K18-ACE2 transgenic mice
vaccinated with VAANZ-W_RRN were completely protected from live SARS-CoV-2 intranasal
challenge"

"we describe a novel RBD-based protein vaccine (VAANZ-delta_RRN) that is highly immunogenic, expresses well, and has a good stability profile. We showed that the incorporation of an NTD... correlated with improved antibody function."

I like that this article links to a number of related sources. And what do they do with all the female mice that are born?

"The female presence in labs is completely under-represented, and I'm not talking about humans here, but mice. The most used animal model in laboratories across the world to discover and test new medicines are almost entirely male."
https://www.understandinganimalresearch.org.uk/news/why-we-need-female-mice-in-drug-trials
--
#InMice

Back before #EmperorPayPaltine, one of my favorite #Twitter accounts was @inmice (#InMice). Whenever someone posted a media article saying something about human health when it was actually based only on studying mice, it would reply with just this text:

IN MICE

Time.com: Scientists develop a procedure #InMice for cellular rejuvenation using a genetic treatment that essentially "reboots" the cell's epigenomic damage. This holds the promise to enable doctors to bring any organ or organism to any biological age at will.

https://time.com/6246864/reverse-aging-scientists-discover-milestone/

The Peña Lab is HIRING! Currently seeking 1-2 #postdocs (molecular or #datascientists) for multiple funded projects to understand how #earlylifestress impacts #epigenetic regulation of brain development and behavior.

We use #singlecell and other #sequencing approaches, computational analyses, and test our hypotheses back in vivo by gene and epigenome editing, activity manipulations, and pharmacological approaches - and of course behavior #inmice.

More here --> www.PenaLab.org

"Genesis of fecal floatation is causally linked to gut microbial colonization in mice"

At least in mice, we may finally know what makes floaters float. It's all about the bacteria in the gut.

https://www.nature.com/articles/s41598-022-22626-x

#Science #Biology #InMice

Let #InArmadillos be the new #InMice

@JoseEdGomes I remember people used to use the hashtag #InMice to flag up misleading titles/headlines about human diseases! 😂

(I agree the model org should be in the title or at least the abstract!)

A New Brain Implant Automatically Detects and Suppresses Pain in Real Time #InMice
https://singularityhub.com/2021/06/29/a-new-brain-implant-automatically-detects-and-kills-pain-in-real-time/