'Altogether, our study identifies an unappreciated site of Yersinia colonization within the murine intestinal mucosa, and reveals an essential function for inflammatory monocytes in maintainance of pyogranuloma architecture during Yp infection.'
fm @BrodskyLab et al

#InfetionImmunity #Plague #Yersinia #Immunology #InnateImmunity

https://www.nature.com/articles/s41564-023-01338-6

'Altogether, our study identifies an unappreciated site of Yersinia colonization within the murine intestinal mucosa, and reveals an essential function for inflammatory monocytes in maintainance of pyogranuloma architecture during Yp infection.'
fm @BrodskyLab et al

#InfetionImmunity #Plague #Yersinia #Immunology #InnateImmunity

"And a grim report today in The Lancet and being presented at a conference in Seattle, which analyzes the death last summer in Mexico and the cases of 381 other mpox patients who also had advanced HIV infections, makes clear the disease poses an enormous risk to those living with uncontrolled HIV. Of the 179 patients with less than 200 CD4 cells per microliter—more than 500 is considered normal—27 died."

#monkeypox #AIDS #HIV #InfectiousDisease #InfetionImmunity

https://www.science.org/content/article/case-studies-expose-deadly-risk-mpox-people-untreated-hiv#.Y_VKFb_W9eA.linkedin

"Thus, studies of MSMD (Mendelian susceptibility to mycobacterial disease ) have revealed that human antimycobacterial immunity is a genetically controlled quantitative trait: the lower the level of IFN-γ activity, the more severe the disease and the higher its penetrance"

#immunology #InfetionImmunity #InfectiousDisease #mycobacterium #tuberculosis

https://www.cell.com/cell/fulltext/S0092-8674(22)01581-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015811%3Fshowall%3Dtrue

'Two weeks after the last dose, antibodies to P. falciparum circumsporozoite protein and PfSPZ were higher in protected versus unprotected vaccinees. A three-dose regimen of PfSPZ Vaccine demonstrated safety and efficacy against malaria infection in malaria-experienced adults.'

#Immunology #Malaria #InfetionImmunity #vaccine
https://www.science.org/doi/full/10.1126/scitranslmed.abj3776?af=R

'Virulence of C. difficile also has an intimate relationship with nutrient availability as, upon nutrient limitation in the gut environment, C. difficile responds by producing toxins that liberate host-derived nutrients through cytotoxic activity and creation of a proinflammatory environment'

#Clostridium #InfetionImmunity "Metabolism #Microbiology

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011034

"Here, we investigated the fetal hematopoietic response to maternal infection with Toxoplasma gondii (T. gondii), an intracellular parasite that elicits Type II IFNγ-mediated maternal immunity."

#immunology #Parasitology #Toxoplasma #HostPathogen #InfetionImmunity #Preprint

https://www.biorxiv.org/content/10.1101/2022.11.29.518417v3

"By conducting a pangenomic screen of the plant pathogen #Pseudomonas syringae, we found 13 type III effectors that potentially possess NADase activities, indicating that NAD+ manipulation is an important virulence mechanism."

#HostPathogen #InfetionImmunity #Metabolism

https://www.pnas.org/doi/10.1073/pnas.2217114120

"Following infection, hematopoietic stem and progenitor cells (HSPCs) support immunity by increasing the rate of innate immune cell production but the metabolic cues that guide this process are unknown. To address this question, we developed MetaFate, a method to trace the metabolic expression state and developmental fate of single cells in vivo."

#Preprint #Metabolism #InfetionImmunity #InnateImmunity #Immunology

https://www.biorxiv.org/content/10.1101/2023.01.24.525166v1?med=mas