WikiPathways · @wikipathways
62 followers · 21 posts · Server fosstodon.org
KDM6A depletion in breast epithelial cells leads to reduced sensitivity to anticancer agents and increased TGF-β activity. https://doi.org/10.1158/1541-7786.MCR-21-0402 #Kdm6a #DrugResistance #TgfΒ
Les Sutton · @LeslieSutton
57 followers · 79 posts · Server fediscience.orgHi #ScienceMastodon - my lab's most recent findings just hit preprint here: https://www.sciencedirect.com/science/article/pii/S0022202X22018887?via%3Dihub
We discovered a #mousemodel for examining #cSCC where #mice with epidermal deficiency of #KDM6A and #P53 show 100% penetrant, spontaneous cSCC development within a year!
#dermatology and #skincancer have very few models to study cSCC in mice and our lab found one!
#cancer #epigenetics #academicchatter #derm #tumorsuppressors #tumor #scicomm
#scicomm #tumor #tumorsuppressors #Derm #academicchatter #epigenetics #cancer #skincancer #dermatology #P53 #KDM6A #mice #CSCC #mousemodel #ScienceMastodon