Newly identified #protein regulates the creation of #cellulose in #plant cells.
https://phys.org/news/2023-07-newly-protein-creation-cellulose-cells.html
#protein #cellulose #plant #Kinase #cpk32
Newly discovered #signaling pathway protects stem #cells in #plant #roots from salt #stress.
https://phys.org/news/2023-05-newly-pathway-stem-cells-roots.html
#signaling #cells #plant #roots #stress #Kinase #gso1
Our latest work is out now in @Circ_Gen! 🎉
❗️Genetic variants in #TNNI3K are associated with dilated cardiomyopathy and supraventricular arrhythmias
#DCM #Arrhythmia #Genetics #Kinase #cardiology Big big thanks to all co-authors! @_CarolinePham Karolina Andrzejczyck, @JurgensSean, @steven_lubitz, @patrick_ellinor, @Jael_Copier, @ArthurWilde5, @cbezzina1, @eml314 and others ✨
https://www.ahajournals.org/doi/abs/10.1161/CIRCGEN.122.003975
#tnni3k #dcm #arrhythmia #genetics #Kinase #cardiology
Molecular module coordinates #plant #cell #wall formation and adaptive #growth.
#signalling #kinase #cellulose #CSK1 #VND6
https://phys.org/news/2023-04-molecular-module-cell-wall-formation.html
#plant #cell #wall #growth #signalling #Kinase #cellulose #csk1 #vnd6
Dissecting the #circadian clock in real time.
#circadian #signalling #cyanobacteria #Kinase
Helping #plants grow as #phosphorus levels in #soil deplete.
#plants #phosphorus #soil #Kinase #Tor #gene #regulation
What is the role of #DNAdamage #kinase #DNAPKcs in the cellular response to #oxidative stress?
Benjamin Chen at UT Southwestern, Hsinyu Lee at National Taiwan University, and coworkers implicate it as part of a #checkpoint that modulates #ANT2-#VDAC2-mediated ADP-ATP exchange over #mitochondrial membranes to limit #OXPHOS-derived ROS
#dnadamage #Kinase #dnapkcs #oxidative #checkpoint #ant2 #vdac2 #mitochondrial #oxphos
#DNAdamage #DNArepair #kinase #DNAPK and #cGAS synergize to induce cancer-related #inflammation in #glioblastoma
Clara Taffoni, Johanna Marines, Nadine Laguette et al at IGH Montpellier
https://www.embopress.org/doi/10.15252/embj.2022111961
#dnadamage #DNARepair #Kinase #dnapk #cgas #inflammation #glioblastoma
#Funfact #structuralbiology The #PDB code for the crystal structure of the active form of the MAP #kinase ERK2 is 2ERK 😬
#Kinase #pdb #StructuralBiology #FunFact
My latest #compchem paper published in #ScientificReports
nature.com/articles/s41598-022-25603-6
#moleculardynamics #simulation of Src family Tyr #kinase Lck in a #Tcell #membrane environment: Full-length #protein dynamics, #lipid interactions, conformational change.
Study highlights: twitter.com/DJ_Biophys/status/1525101069332021248
#compchem #ScientificReports #moleculardynamics #simulation #Kinase #Tcell #membrane #protein #lipid
Internally, adenosine is transformed into inosine and S-(5′-Adenosyl)-L-homocysteine (AdoHcy) by adenosine deaminase (ADA) and S-adenosyl-L-homocysteine hydrolase (SAHH) respectively. Additionally, adenosine #kinase helps to maintain the concentration of adenine #nucleosides/#nucleotides by converting adenosine into adenosine monophosphate. Finally, during cellular injury or hypoxia/#ischemia, adenosine is formed from #ATP and is transported inside the #cell using #transmembrane proteins.
#Kinase #nucleosides #atp #cell #transmembrane
Researchers find repeated #gene duplications and genetic diversification in protein #kinase R in mouse-eared #bats.
https://phys.org/news/2022-11-gene-duplications-genetic-diversification-protein.html
#gene #Kinase #bats #PKR #EIF2AK2 #phylogenetics
RT @MolMetab@twitter.com
This paper by Anna Juliane Vesting et al. shows that #hepatocyte-specific loss of the NFκB-inducing #kinase (NIK) improved #metabolic #NASH complications and reduced #hepatocarcinogenesis.
👩🔬👨🔬@MPI_Metabolism@twitter.com @UniCologne@twitter.com @HIMAG_Leipzig@twitter.com
➡️https://www.sciencedirect.com/science/article/pii/S2212877822001958
#hepatocarcinogenesis #nash #metabolic #Kinase #hepatocyte
An excellent #Review by Jacob #McPhail and John #Burke on the #PI4K #kinase role in #viral #replication.
https://onlinelibrary.wiley.com/doi/full/10.1111/tra.12841
#review #viral #McPhail #burke #PI4K #Kinase #replication
Amazing work showing that #genetic #disruption of the #kinase module (CDK) of Mediator complex in chimeric #antigen receptor T cell (CAR T) resulted in enhanced effector function and increased #antitumor activity (disruption of CDK module increases core Mediator #chromatin occupancy at #enhancers)
#enhancers #chromatin #Antitumor #antigen #Kinase #disruption #genetic #paperoftheday
#IDMastodon #immunology Enhanced #Tcell effector activity by targeting the Mediator #Kinase module
https://www.science.org/doi/10.1126/science.abn5647 @aaas
https://twitter.com/katieannfreitas/status/1591151851902468096?s=61&t=WBA5Y5zuxKQ8VYpY10r5uw🧵@KatieAnnFreitas
#IDMastodon #immunology #TCell #Kinase
I'd better do another #introduction now I've moved my #fediverse home.
Hi, I'm Dave. I'm a Principal Laboratory #Research #Scientist (aka. Scientific officer) at the Francis Crick Insititute in #London.
I'm a #StructuralBiologist by training. I help run a group that studies #Kinase #signaling in human #health and #disease.
I do #Crystallography #CryoEM #Biophysics #DrugDesign and #Glycobiology. #Science
#Science #Glycobiology #DrugDesign #Biophysics #cryoem #crystallography #disease #health #signaling #Kinase #StructuralBiologist #London #scientist #research #fediverse #introduction