Aled · @aledmedwards
32 followers · 309 posts · Server mstdn.science
RT @thesgconline
🧠TTBK1/2 are understudied #kinases, expressed in the brain.
Check out how SGC at @UNCPharmacy has developed high-quality, cell-active, small-molecule inhibitors of TTBK1/2 and illustrated their impact on ciliogenesis.
Dave Briggs :protein: · @xtaldave
1343 followers · 1125 posts · Server xtaldave.netCryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention
#StructuralBiplogy #CryoEM #Kinases @strucbio https://www.pnas.org/doi/abs/10.1073/pnas.2300054120?af=R
#structuralbiplogy #cryoem #Kinases
The EMBO Journal · @embojournal
424 followers · 130 posts · Server sciencemastodon.com
Two #Hippo signaling modules converge on the #kinases #LATS1/2 to differentially regulate #YAP/#TAZ activation, orchestrating liver size and #tumorigenesis
Sixian Qi, Zhenxing Zhong, Fa-Xing Yu et al
#hippo #Kinases #lats1 #yap #tumorigenesis
Alexey Veraksa · @veraksa
90 followers · 131 posts · Server drosophila.socialAn amazing resource surveying substrate specificity for 303 human Ser/Thr #kinases:
https://www.nature.com/articles/s41586-022-05575-3
Dave Briggs :protein: · @xtaldave
1162 followers · 3332 posts · Server xtaldave.net🚨 New Preprint from our lab 🚨
Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface
https://www.biorxiv.org/content/10.1101/2023.01.03.522491v1?rss=1
#Kinases #polarity #Science #research #cellbiology
Dave Briggs :protein: · @xtaldave
695 followers · 919 posts · Server xtaldave.net
Single molecule phosphorylation napping using nanopore!
Seems pretty damn amazing & useful
#Science #Kinases #NanoPore
https://www.biorxiv.org/content/10.1101/2022.11.11.516163v1?rss=1
TrangAston :verified: · @CastlTrAstonDrs
251 followers · 210 posts · Server med-mastodon.com
#IDMastodon #Kinases key regulators of the #innateimmunity.The discovery of novel small molecule modulators is critical to new Tx for #antiviral and #cancer #Immunotherapy. The Transcreener ADP2 Kinase Assay can help accelerate these efforts due to its robust flexibility for #DrugDiscovery
https://offers.the-scientist.com/hubfs/TS_PPL_Bellbrook_Kinases_Article/Targeting_Kinases_Involved_in_the_Innate_Immune_Response.pdf?utm_referrer=https%3A%2F%2Foffers.the-scientist.com%2F by @TheScientistLLC
#IDMastodon #Kinases #innateimmunity #Antiviral #cancer #Immunotherapy #DrugDiscovery
Dave Briggs :protein: · @xtaldave
692 followers · 913 posts · Server xtaldave.net#Science #research #Biology #Chemistry #ChemicalBiology #MedicinalChemistry #StructuralBiology #Crystallography #CryoEM #Kinases #Signalling #DrugsDesign #Protein #Glycobiology #Glycotime #ProteinFolding #Synchrotron #London #Deptford #UK #noxp
#noxp #uk #Deptford #London #synchrotron #ProteinFolding #Glycotime #Glycobiology #protein #DrugsDesign #Signalling #Kinases #cryoem #crystallography #structuralbiology #MedicinalChemistry #ChemicalBiology #chemistry #Biology #research #Science