Rana Ramadan and colleagues show that extracellular matrix #remodelling plays a role in the maintenance of #intestinal stem cells and crypt morphology both during #development and in the adult mouse #gut:
#StemCells #ECM #Laminin #Science #BiologyOpen #Biology #AcademicMastodon
#remodelling #intestinal #development #gut #stemcells #ECM #Laminin #Science #biologyopen #biology #AcademicMastodon
Katajisto &co show that laminin matrix adhesion regulates basal mammary epithelial cell identity: https://journals.biologists.com/jcs/article/135/23/jcs260232/285829/Laminin-matrix-adhesion-regulates-basal-mammary
#cellbiology #research #sciencemastodon #science #laminin #basementmembrane
#cellbiology #research #sciencemastodon #Science #Laminin #basementmembrane
I came across this #microscopy paper. https://www.nature.com/articles/s41587-022-01519-4
"By blue-shifting the #STED beam and separating #fluorophores by on/off switching, individual fluorophores bound to a #DNA strand are localized with σ = 4.7 Å, corresponding to a fraction of the fluorophore size, with only 2,000 detected #photons ."
This image showing resolution below the size of the fluorophore leaves me speechless.
The paper features images of #DNAorigami, #NuclearPores, synaptic #Vesicles, #ECM (#laminin) and #vilmentin
#Sted #dna #microscopy #photons #vilmentin #Vesicles #fluorophores #DNAorigami #NuclearPores #ecm #Laminin
One of the best thing about #StructuralBiology (IMO) is the ability to present your 3D models as gorgeous #rendered images.
I've recently been learning to use @Blender to render some of my structures.
This image shows part of a protein called #Laminin (grey surface) which coordinates a Calcium ion (glowing Cyan sphere) to bind to a polysaccharide (sugar) called #Matriglycan (chemical structure).
#Biochemistry #Science #crystallography #Matriglycan #Laminin #rendered #structuralbiology