#IDMastodon #Epigenetics & clinical observations referring to Betacoronavirus lead to the conjecture that #SARSCoV2 🦠 may have the ability to infect #Lymphocytes using a different way than the spike protein. In addition to inducing the death of lymphocytes, thus drastically reducing their population & causing a serious #immunedeficiency allows it to remain hidden for long periods of latency using them as a #viralreservoir in #LongCovid

@vdumeaux @cyrilpedia @gpollara Which brings on the #immunology in #oncology story of tertiary lymphoid structures #tls TLS and their role in anti-tumor #immunity ...from #lymphocytes to antigen-presenting #Bcells and #Immunotherapy responses. https://pubmed.ncbi.nlm.nih.gov/31942075/

RT @BloodScientist@twitter.com

#MorphologyMonday

Lymphocytes can come in all different shapes and sizes. Here are 4. Can you name each and when you may see them.

#OnlyCells #Lymphocytes #underthescope
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📸1-3: Personal photography
📸4: ASH image bank

🐦🔗: https://twitter.com/BloodScientist/status/1617431952398729217

#MorphologyMonday

Lymphocytes can come in all different shapes and sizes. Here are 4. Can you name each and when you may see them.

#OnlyCells #Lymphocytes #underthescope
_____
📸1-3: Personal photography
📸4: ASH image bank

#Covid #jab #spikeproteins #cause #lymphocytes to “chew a hole in the #aorta,” warns Dr. Cole https://bit.ly/3VRvvwN

Manufacture and Characterization of GMP-Compliant #SARS-COV-2 Cytotoxic T #Lymphocytes, The Journal of Infectious Diseases, jiac500, https://doi.org/10.1093/infdis/jiac500

The delicate balance between CD4 and CD8 T cells within solid tumors: a new aspect of the role of CD4 T cells in a glioblastoma model reveals possible synergies with a CD40 agonistic approach. #immunology #Oncology #Immunotherapy #Lymphocytes
https://jitc.bmj.com/content/10/12/e005293

Regulatory T cells revisited...from the "brakes" of the immune response to master regulators: here is a fresh review on the complex role of this immune cell subpopulation #immunology #Lymphocytes @cyrilpedia @gpollara @rio_sugimura
https://academic.oup.com/cei/advance-article/doi/10.1093/cei/uxac123/6961023?searchresult=1

Ogura, H., Gohda, J., Lu, X. et al. Dysfunctional #Sars-CoV-2-M protein-specific #cytotoxic T #lymphocytes in patients recovering from severe #COVID19. Nat Commun 13, 7063 (2022). https://doi.org/10.1038/s41467-022-34655-1

Visualizing localization of #Lymphocytes during #Immunotherapy in human patients with PET-imaging revealed massive and surprising #Heterogeneity in CD8+ T cell distribution and #Pharmacodynamics within and between patients https://www.nature.com/articles/s41591-022-02084-8

Tumor-infiltrating lymphocytes are key players in the tumor #microenvironment and for #Immunotherapy ...but how do we bring these #Lymphocytes into it? Here are some suggestions... https://pubmed.ncbi.nlm.nih.gov/36366354/

Treating dangerous forms of cancer is seeing continued progress in the medical world, with highly lethal advanced melanoma being the target in this case.

Dutch scientists have found that treatments involving tumor infiltrating lymphocytes have shown a survivability increase of several months as compared to other methods.

An ongoing work in progress and not yet a cure, but a promising outcome.

#Cancer #Melanoma #Lymphocytes #TIL #Medicine #sciencemastodon #scicomm

https://www.nejm.org/doi/10.1056/NEJMoa2210233

RT @MadhviM@twitter.com

‼️Interested in how and why the immune response differs between men and women? ‼️

Happy to share our latest review article👇 on the #sexbias in #lymphocytes and it’s implications for #autoimmune diseases @KatyCDodd@twitter.com @FrontImmunol@twitter.com

https://www.frontiersin.org/articles/10.3389/fimmu.2022.945762/full

🐦🔗: https://twitter.com/MadhviM/status/1596558544639528961

RT @CSU_MIP
#MIP professor @alanschenkel, @NJHealth and @CUAnschutz researchers found many kinds of killer #Lymphocytes, which are important in fighting viruses and intracellular bacteria. To their surprise, they also found very few neutrophils, which usually fight extracellular #Pathogens.