Genomic binding & transcriptional activation by #Myc are controlled by #TXNIP, whose expression is linked to cellular energy status, thereby connecting Myc transcriptional activity to cell #metabolism & nutrient status @yehpeace @GertzLab #PLOSBiology https://plos.io/3FCCJyV

Genomic binding & transcriptional activation by #Myc are controlled by #TXNIP, whose expression is linked to cellular energy status, thereby connecting Myc transcriptional activity to cell #metabolism & nutrient status @yehpeace @GertzLab #PLOSBiology https://plos.io/3FCCJyV

Genomic binding & transcriptional activation by #Myc are controlled by #TXNIP, whose expression is linked to cellular energy status, thereby connecting Myc transcriptional activity to cell #metabolism & nutrient status @yehpeace @GertzLab #PLOSBiology https://plos.io/3FCCJyV

Some new cancer news for y'all.

The MYC family of regulatory genes help control cell growth and proliferation and are known to be constantly on in cancerous cells.

Now, researchers at the University of Würzburg have found that these MYC proteins form into spheres under stressful conditions, thereby causing the proliferation.

Destroying them would also likely kill the cancer cell they belong to.

#Cancer #Biology #Medicine #MYC #sciencemastodon #scicomm

https://www.nature.com/articles/s41586-022-05469-4

Drugging undruggable is becoming a reality in Myc-driven cancers #Myc #Cancer https://www.nature.com/articles/d41573-022-00192-1

Hello everyone, I'm a scientist who now writes about cool science in the oncology arena. Currently interested in #TPD #KRAS #MYC and other emerging areas of interest.