From their abstract:
"Emerging evidence suggests that understanding of #timescales may be important in resolving this issue, but that further work is needed to understand the role of adhesive strengthening across scales."

Same the conclusion as in our theory paper https://doi.org/10.1371/journal.pcbi.1009812 : the interplay of #cadherin #adhesion & cortical #actomyosin timescales triggers emergent phenomena in terms of #tissue mechanics. If one adds #mechanotransduction on top of that then expect awesome effects.

"Single-molecule magnetic tweezers to capture over a million individual transitions as a single talin protein unfolds and refolds under force in equilibrium. When observed at classically probed timescales, talin folds in an apparently uncomplicated two-state manner. As the sampling time extends from minutes to days, the underlying energy landscape exhibits gradually larger signatures of complexity, involving a finite number of well-defined rare conformations.[...]The physiological relevance of each distinct conformation can be connected to the binding of the cytoskeletal protein vinculin, suggesting an extra layer of complexity in talin-mediated mechanotransduction."
https://www.nature.com/articles/s41567-022-01808-4
#StructuralBiology #Talin #Vinculin #MechanoTransduction #MechanoBiology #Cytoskeleton