New ChemRxiv preprint! “Pitfalls and considerations in determining the potency and mutant selectivity of covalent #EGFR inhibitors.” Collaboration between our group and AssayQuant Technologies, Inc. #MedicinalChemistry #oncology https://chemrxiv.org/engage/chemrxiv/article-details/64e50861dd1a73847f5020a1

You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 Beilstein Journal of Organic Chemistry. #BJOC

🔗 https://www.beilstein-journals.org/bjoc/series/123/?M=y

#Electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience

RT @School_Pharmacy
We're looking for a highly motivated #ResearchFellow in #ProteinScience to join our team and contribute to our research projects in #MedicinalChemistry.

The deadline for applications is 16 April. To find out more and to apply, visit: https://bit.ly/3ZCQEMA @MatToddChem

@heppnerd Congrats on the new role, Dave! Nicely done.
#medicinalchemistry

RT @cressetgroup
💬 A glowing review for Flare™ from The University of Cambridge!

⭐⭐⭐⭐⭐

https://www.cresset-group.com/software/flare/

#university #academia #drugdiscovery #medicinalchemistry #drugdesign #medchem #computationalchemistry #compchem #cheminformatics #CADD

NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.

https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#

Announcement I've been sitting on: I'm joining UCI's new Institute for Neurotherapeutics! While Rob Spitale (@SpitaleLab@twitter.com) is affiliated with the INT he is on leave from the university (hence my job change) and I'll be working for Brian Paegel (@BrianDNA@twitter.com) and INT director Al La Spada.

https://news.uci.edu/2022/10/18/uci-launches-center-for-neurotherapeutics-to-facilitate-drug-discovery-and-therapy-delivery/

#UCI #Neurotherapeutics #Chemistry #ChemicalBiology #ChemBio #ChemiVerse #MedChem #MedicinalChemistry #DrugDiscovery #Collaboration #Science

Hi All, new on Mastodon, I am happy to share our website opnMe.com which support for free academic scientists with high quality tool compounds free of charge. Visit us. opnMe is the open innovation website of Boehringer Ingelheim
Florian
#medicinalchemistry

Viva 3 ✔️

Congratulations to the new Dr. Will on completing his PhD viva. Will’s project was on the design, synthesis and testing of libraries of protein degraders, and he is now putting his training in #MedicinalChemistry and #TPD into good use in his new job at GSK. That’s all for #ThreeVivaFortnight - but we don’t have long to wait before the next one - Dani’s transfer viva in two weeks time!

Always sad to say goodbye but great to celebrate our #PhD students progressing!

Viva 2 ✅ Congratulations Katie on completing transfer viva for formal registration as a PhD student. Katie’s project is on designing, making and testing monovalent degraders, working across our chemistry and biology teams in the #CCDD (Centre for Cancer Drug Discovery) at ICR.

#TPD #MedicinalChemistry #Chemistry

-Time for a short #Introduction-

I am a group leader in #MedicinalChemistry at the University of Parma. My lab combines #chemical & #computational techniques to develop novel pharmacological tools to study different Chronic Diseases (#CysticFibrosis, #IBD, #Hypercholesterolemia, #Alzheimer, #Cancer) and Infective Agents (#SARSCoV2, #Enterovirus, #Flavivirus, #Monkeypox, #HIV).
We are particularly interested in the development of #MultiTarget inhibitors and open to new #collaborations in #DrugDiscovery.
#Tooting (sooner or later) about the #chemistry and #science

It’s a Three Viva Fortnight in our team!

One down …
Viva 1: Charlie (PhD) today ✅

And two to go …
Viva 2: Katie (transfer to PhD) on Thursday
Viva 3: Will (PhD) next Thursday

Congratulations to the new Dr. Charlie!
Great to see talented scientists ticking off another milestone, and a relief to see that the first project proposal I was responsible for writing didn’t end in disaster…!

Thanks to the examiners for giving up their time and effort!

#PhD #MedicinalChemistry #ICR #celebrate

Some nice work from Ethan Toriki, James Papatzimas, Daniel Nomura and coauthors on bioRxiv https://www.biorxiv.org/content/10.1101/2022.11.04.512693v1

I think this is the first example in the “glue degraders” field where someone found a “degrading handle” that could be attached to multiple different inhibitors to give degradation of different proteins. A nice step forward in the rational design of molecular glue degraders!

#TPD #MedicinalChemistry #degraders

I will try and use this account to
- share some nice science (from us and other
- ask and answer questions about research
- explain some key concepts about my work (good #SciComm practice!)

Always happy to hear from people who want to know more, or who are interested in careers in #MedicinalChemistry or #DrugDiscovery

I’m on this Sci Comm server because I like to try to explain things to people with different backgrounds, but that doesn’t mean I’m good at it, so bear with me!

I’m a researcher in #MedicinalChemistry - I design and make chemicals towards medicinal application at the Institute of #CancerResearch.

One focus is on #TPD - targeted protein degradation, a relatively new area, where we aim to find molecules that dont just block the function of a protein, but wipe it out completely.

I believe sharing knowledge is absolutely critical to science (Here’s me trying some #scicomm at Pint of Science 2022!) - so ask me anything about #DrugDiscovery!

#Science #research #Biology #Chemistry #ChemicalBiology #MedicinalChemistry #StructuralBiology #Crystallography #CryoEM #Kinases #Signalling #DrugsDesign #Protein #Glycobiology #Glycotime #ProteinFolding #Synchrotron #London #Deptford #UK #noxp

#introduction

Hi there! My name is Cedric and I'm a synthetic medicinal chemist. I design and develop new molecules hoping to find something useful to treat neglected tropical diseases such as #Malaria, #Leishmaniasis and #Chagas disease.

Currently I am a #MedicinalChemistry trainer at the Wellcome Centre for Anti-Infectives Research at the University of Dundee, Scotland. My interests are #chemistry, #DrugDesign, #compchem and some #python on the side.