Next is Melanie Samuel from BCM
thesamuellab.org/

Molecular regulation of cell and function in the

"Our brain is the ultimate time machine" 🙂

How to target (for intervention) while preserving them (to avoid "turning back the clock"

Possibility that could be harnessed

partnered with IMPC (impc.org) to find microglia regulators in retina
one cool hit: SIRPα
it's NOT involved in ... surprise

1/2

#cssinglecells23 #phagocytosis #Microglia #synapses #brain #plasticity #immune

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1890 followers · 10951 posts · Server qoto.org

'One may even speculate that there might be individual microglial populations that are specialized to deal with the different pathological challenges of AD. Thus, microglial activation is an integral component of the amyloid cascade and not just an alternate disease-causing pathway unrelated to amyloid-driven events.'

journals.plos.org/plosbiology/

#neuroimmunology #alzheimers #Microglia #immunology

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1844 followers · 9941 posts · Server qoto.org

'For example, loss of function of the microglial gene Trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and Trem2 variants are among the strongest genetic risk factors for AD. Thus, restoring microglial function represents a rational therapeutic approach. Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a Trem2 mutant mouse model of AD.'

cell.com/cell-stem-cell/fullte

#alzheimer #Microglia #neuroimmunology #neurodegenerativedisease

Last updated 1 year ago

PLOS Biology · @PLOSBiology
5191 followers · 1659 posts · Server fediscience.org

play a dual role in depending on their pro- vs anti-inflammatory polarization. Yao Yao explores a study showing how the TF NR4A1 negatively regulates TNF expression in microglia. Paper: plos.io/3Q4w4n8 Primer: plos.io/43JAq6m

#plosbiology #stroke #Microglia

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1666 followers · 8024 posts · Server qoto.org

"In this article, we show that HIV-infected human microglia express increased levels of TREM1 and are resistant to HIV-induced apoptosis. Moreover, upon genetic inhibition of TREM1, HIV-infected microglia undergo cell death in the absence of increased viral or proinflammatory cytokine expression or the targeting of uninfected cells."

journals.aai.org/jimmunol/arti

#infection #immunity #virology #hiv #Microglia

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1663 followers · 7902 posts · Server qoto.org

Interesting addition to the toolbox, if you're working on :

"We generated a constitutive Cre line controlled by the microglia signature gene Crybb1 that produced nearly complete recombination in embryonic brain macrophages (microglia and border-associated macrophages [BAMs]) by the perinatal period, with limited recombination in peripheral myeloid cells."

cell.com/immunity/fulltext/S10

#Microglia

Last updated 1 year ago

Thiago Carvalho · @cyrilpedia
1658 followers · 7730 posts · Server qoto.org

IL6 is not always the bad guy.

"In the penumbrae of human stroke brain lesions, we identified a subpopulation of microglia that express vascular endothelial growth factor A. These cells, termed ‘repair-associated microglia’ (RAMs), were also observed in a rodent model of CVI and coexpressed interleukin (IL)-6Ra. Cerebrovascular repair did not occur in IL-6 knockouts or in mice lacking microglial IL-6Ra expression"

nature.com/articles/s41590-023

#Microglia #neuroimmunology #immunology #inflammation

Last updated 1 year ago

JamesLundblad · @JamesLundblad
20 followers · 312 posts · Server mstdn.social
The vOICe vision · @seeingwithsound
356 followers · 960 posts · Server mas.to

Microglia enable cross-modal plasticity by removing inhibitory synapses (in mice) cell.com/cell-reports/fulltext "Visual deprivation increases visual cortex (V2L) excitability during whisker stimulation", "Microglia phagocytose local inhibitory synapses to unmask cross-modal plasticity"

#neuroscience #plasticity #crossmodal #Microglia

Last updated 2 years ago

Albert Cardona · @albertcardona
1703 followers · 1966 posts · Server mathstodon.xyz

@eLife

Nice video of neuronal activity!

"Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice"
Nebeling et al. 2023 elifesciences.org/articles/831

Editor evaluation: "This work provides insights into the use of anesthetics in measuring cellular dynamics, regional differences in plasticity, and neuronal activity regulation of microglia dynamics. It is an important contribution to understanding hippocampal microglia plasticity in adulthood."

#hippocampus #mouse #neurons #Microglia #neuroscience

Last updated 2 years ago

DiverseTCR · @Saligramalab
66 followers · 63 posts · Server mstdn.social

for In situ Patch-seq analysis of microglia reveals a lack of stress genes as found in FACS-isolated microglia biorxiv.org/content/10.1101/20

#experts #Microglia #paper

Last updated 2 years ago

Inside The Match · @inside_thematch
96 followers · 1936 posts · Server med-mastodon.com

RT @sadagurski
@sadagurski's lab is HIRING!! We are looking for a talented interested in the hypothalamic regulation of metabolism, and biology! We have some exciting new funded and we'd love a new, enthusiastic team member! If interested DM me

#postdoc #Microglia #Astrocytes #nih #coolprojects

Last updated 2 years ago

AnnaMolofskyLab · @AnnaMolofskyLab
0 followers · 1 posts · Server mstdn.social

Trying the switch. Our lab loves signaling, and all things and

#immunology #NeuroScience #Microglia #neuroimmune

Last updated 2 years ago

Joe Sabatino · @jsabatino37
68 followers · 100 posts · Server fediscience.org

Really provocative new study on changes in normal appearing white matter in with increased activation and perivascular accumulation

onlinelibrary.wiley.com/doi/10

#TCell #Microglia #multiplesclerosis #myelin

Last updated 2 years ago

Brent Stockwell · @bstockwell
215 followers · 25 posts · Server toot.community

A recent paper by Tim Hammond's team at Sanofi showed that in the undergo and drive , such as 's and . Here are my thoughts on why this is exciting. brentstockwell.medium.com/ferr

#Microglia #brain #Ferroptosis #neurodegeneration #Parkinson #ALS

Last updated 2 years ago

Kevin Tu · @kevintu
2 followers · 2 posts · Server mas.to

We found novel microglia subtypes induced by the combination of Aβ and tau pathologies in a disease stage-specific manner in Alzheimer's disease. Hot off the press!

doi.org/10.1186/s13024-022-005

#neuropathology #tau #siglec #Microglia #alzheimers

Last updated 2 years ago

David Mason · @dn_mason
106 followers · 24 posts · Server mas.to

Working with for today. They can be fiendishly tricky to segment given their highly variable morphology and long cell extensions.

#fluorescencefriday #Microglia

Last updated 2 years ago

David Mason · @dn_mason
158 followers · 107 posts · Server mas.to

Working with for today. They can be fiendishly tricky to segment given their highly variable morphology and long cell extensions.

#fluorescencefriday #Microglia

Last updated 2 years ago

genomeresearch · @genomeresearch
441 followers · 4 posts · Server genomic.social

New in @genomeresearch: Mosaic loss of Y (LOY) was enriched in cells, increased with age, and was elevated in ’s and Huntington’s disease donors.🧠 Free article here: ow.ly/JSc250LZzlX #

#Chromosome #Microglia #Alzheimer #openaccess

Last updated 2 years ago

Hao Yin · @HaoYin
173 followers · 119 posts · Server qoto.org

jointly degrade fibrillar α-Synuclein cargo by distribution through

-mediated social behaviors of Microglia

Microglia take α-Synuclein from & send Mitochondria to overloaded neighbors

Dr, Michael Heneka lab @cellcellpress@twtr.plus2021
cell.com/cell/fulltext/S0092-8

#Microglia #TunnelingNanoTube

Last updated 2 years ago