#Phosphorylation control in #mitosis:
Julie Welburn and colleagues reveal the molecular basis for #cellcycle regulation of #Kif4A and #CENPE motor interaction with #PRC1, needed to organize antiparallel #microtubule bundles and to ensure central spindle integrity, #midbody assembly and #cytokinesis

https://www.embopress.org/doi/full/10.15252/embj.2023113647

When it comes to atypical #mitoses the #MercedesBenz (tripolar) form are not too uncommon; a #Ferrari #mitosis (prancing horse) on the other hand is a little bit more exotic 😀 #pathology #MedMastodon

Why is a short loop in the extended #Ndc80 #kinetochore complex essential for #mitosis?
In vitro studies by Soumitra Polley @andreamusacchio @microtubule_guy @pim et al reveal its contribution to end-on #microtubule attachment via homotypic interactions between adjacent Ndc80 molecules
https://www.embopress.org/doi/10.15252/embj.2022112504

#Online #morphogenesis #seminars by Lakshmi Balasubramaniam @lakshmib02 “Life and death of cells a mystery solved through #biomechanics”
and by Guy Blanchard @guyblanchard “#Tissue stress #anisotropy and neighbour compression combine in #mitosis to orient #epithelial #cell divisions”

Mon March 6, GMT 2.30pm.

https://ucammorphogenesisseries.com/

@cyrilpedia I've not had a deep read of this 😍 pre-print from Oegama/Desai team but I was struck @StearnsLab about parallels of 'stopwatches' for your work with Emily on Hh, #cilia for how long in #CellCycle determining steps at subsequent #mitosis. This idea of counting time over multiple cycles is very cool. https://www.cell.com/current-biology/pdfExtended/S0960-9822(20)30643-6

We know that #centrosomes are not required for mitotic division, so what are they good for?

New preprint from grad student KC Farrell shows that having two duplicated centrosomes at the beginning of #mitosis facilitates rapid bipolar spindle formation. In the absence of centrosomes there is a checkpoint-mediated delay that is required to give enough time to sort things out and assemble the spindle.

#CellBiology
https://www.biorxiv.org/content/10.1101/2022.11.08.515699v1.full.pdf

@LeBorgneLab Interesting... but I hope final PDF will have better image resolution, I can't see anything on their Fig 4. @mechanobiology Btw, don't forget to tag: #Drosophila #adhesion #mitosis else post will be found by followers only