Welcome @bastien_boussau to Mastodon #MolecularEvolution #bioinformatics #ComputationalBiology

Do you think that using the term “evolutionary rate” for the ratio dN/dS is accurate or misleading?

#MolecularEvolution
#EvolutionaryBiology
#Evolution

Great to see first keynote by an interdisciplinary paleobiologist: Phil Donoghue #smbe2023 #paleontology #MolecularEvolution

I'll be live-posting #SMBE2023 #SMBE23, please mute me for 4 days if you don't want lots of #MolecularEvolution in your timeline.

Announcing #SIB Comparative genomics course, taught by Christophe Dessimoz, Natasha Glover, @rmwaterhouse and myself, 30 August - 01 September in Lausanne #UNIL
• Introduction to molecular evolution & phylogenetics
• Orthology-focused arthropod comparative genomics
• Duplication of genes and genomes, expression
with #SIB resources #OMA, #Orthodb #BUSCO and @bgeedb #ortholog #orthologs #paralog #duplication #MolecularEvolution #Genomics #bioinformatics #training @P_Palagi https://www.sib.swiss/training/course/20230830_COMGE

Rps27 and Rps27l proteins are functionally interchangeable...
have been evolutionarily retained because the divergence of their expression patterns has resulted in both genes becoming necessary for achieving adequate total expression of the RP across cell types.

#MolecularEvolution
#Subfunctionalization
#geneduplication
#evolution

https://elifesciences.org/articles/78695

In #Edinburgh for 50th anniversary of #rum #reddeerproject earlier this week. A very impressive and on-going study of #ecology #evolution #lifehistory #molecularevolution of Cervus elaphus L.. Many more eminent attendees than myself (only some found here @MarcoFB). My knowledge of the project was updated a lot.

Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper

Masatoshi Nei, one of the founders of #MolecularEvolution, has died 😢. He was PhD or postdoc advisor to an amazing array of field leaders.

From: @JJ_Emerson
https://ecoevo.social/@JJ_Emerson/110396840914044756

Looks cool: Genomic and transcriptomic analyses support a silk gland origin of spider venom glands https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01581-7 #EvoDevo #MolecularEvolution #Spider #venom

Welcome @jomcinerney to Mastodon #MolecularEvolution #ecoevo

Our latest #preprint develops a new metric of #CodonAdaptation (not just #CodonBias) to measure the kind of #EffectivePopulationSize that matters to #NearlyNeutralTheory, and uses it to discover that #NaturalSelection prefers high #IntrinsicStructuralDisorder https://www.biorxiv.org/content/10.1101/2023.03.02.530449v1 1/6
#MolecularEvolution #PopulationGenetics #EvolgenPaper

#Matreex can also be used for research into gene family evolution, providing a rapid and efficient overview of the gene family over many species. Visualization of intraflagellar transport gene families allowed us to discover complete loss in the #mixozoan Thelohanellus kitauei. #MolecularEvolution

#Matreex can be used for teaching, as here with the classical example of opsin evolution: notice the parallele loss of blue- and green-sensitive opsins in snakes and mammals, the duplications in frugivorous old-world primates, and the duplications and losses in fishes according to habitat. #opsin #MolecularEvolution

Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5

#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper

Ver nice work by Martín-Zamora et al showing the role of #heterochrony of gene expression in the evolution of larva in bilaterians #Annelid #EvoDevo #MolecularEvolution https://doi.org/10.1038/s41586-022-05636-7

Just found the list of symposia of #SMBE23 #SMBE2023 online! Including "Integrating fossils and molecules to reconstruct the evolution of life in deep time" with the @moultdb team and many other cool topics. #MolecularEvolution
http://www.smbe.org/Portals/0/2023%20Meeting/SMBE2023-Symposia%2019%20DEC%202022.pdf

Amazing seminar @dee_unil today by Magdalena Bohutínská (MajdaHolcova on Twitter). A researcher and a research program to follow! #ConvergentEvolution #MolecularEvolution #GenomeDuplication #PlantEvolution
https://ecoevo.social/@dee_unil/109699673384041182

Cool concept by Fukushima & Pollock: measure selective convergent evolution by contrasting convergence (instead of rates) at non synonymous vs synonymous levels. #MolecularEvolution #NaturalSelection
https://doi.org/10.1038/s41559-022-01932-7

Just read "Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans" by Benitiere et al @duret_lbbe, very nice and careful argument that most alternative splicing in e.g. vertebrates is non functional and accumulates neutrally. https://doi.org/10.1101/2022.12.09.519597 #MolecularEvolution #AlternativeSplicing #Neutralism