Marco Radi · @marcoradi
144 followers · 91 posts · Server qoto.org
Happy to share our just accepted #review on #multitarget approaches for the #synthesis of #purine and #pyrimidine derivatives. From the #prebiotic/#abiotic origin of life to new #green #chemistry strategies for #drugdiscovery.
https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ejoc.202201288?utm_source=google&utm_medium=paidsearch&utm_campaign=R3MR425&utm_content=Chemistry
#pyrimidine #drugdiscovery #green #chemistry #review #synthesis #prebiotic #MultiTarget #purine
Marco Radi · @marcoradi
110 followers · 44 posts · Server qoto.org
As additional Appendix to my #introduction, I would like to #boost our recent #DrugDiscovery efforts in the field of #CysticFibrosis: we have developed #MultiTarget compounds acting at the same time as #CFTR #Correctors and #Antibacterials or #Antivirals depending on the specific functionalization of the same chemotype.
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202200277
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01416
#introduction #boost #drugdiscovery #antivirals #cysticfibrosis #MultiTarget #cftr #Correctors #Antibacterials
Marco Radi · @marcoradi
65 followers · 20 posts · Server qoto.org
Possible applications of #MultiTarget compounds in #ProxPharm Beyond PROTACs.
https://www.sciencedirect.com/science/article/pii/S2001037022005049
Marco Radi · @marcoradi
65 followers · 20 posts · Server qoto.org
-Time for a short #Introduction-
I am a group leader in #MedicinalChemistry at the University of Parma. My lab combines #chemical & #computational techniques to develop novel pharmacological tools to study different Chronic Diseases (#CysticFibrosis, #IBD, #Hypercholesterolemia, #Alzheimer, #Cancer) and Infective Agents (#SARSCoV2, #Enterovirus, #Flavivirus, #Monkeypox, #HIV).
We are particularly interested in the development of #MultiTarget inhibitors and open to new #collaborations in #DrugDiscovery.
#Tooting (sooner or later) about the #chemistry and #science
#chemical #computational #cysticfibrosis #Hypercholesterolemia #alzheimer #cancer #SarsCoV2 #enterovirus #Flavivirus #monkeypox #hiv #introduction #MedicinalChemistry #ibd #MultiTarget #collaborations #drugdiscovery #tooting #chemistry #science