De Novo pathogenic variant of miR-145-5p (het?😃) in #MultisystemSmoothMuscleDysfunctionSyndrome #RareDisease

+mRNA & miR transcriptomes of patient skin fibroblast-/+TGFβ1 😋

Dr Mark Lindsay lab JCI 2023
@MarkELindsay
@markelindsay
https://www.jci.org/articles/view/166497

miR-145-5p is a master miRNA to maintain #SmoothMuscleCell contractile phenotype

My favorite among the earliest miR-145 papers👇

Acquisition of the contractile phenotype by murine arterial SMCs depends on the Mir143/145 gene cluster

JCI 2009
https://www.jci.org/articles/view/38864
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miR-145
CARMN
SMILR
...

The (re-)arising of smooth muscle-enriched non-coding RNAs makes me really nostalgic for my PhD days & nights😸 in Calgary