''1 of Arequipa viruses (A/SA sea lion/PeruAQP-SER00R/2023) w/ D701N #mutation clusters on #PB2 tree with #H5N1 isolated from a #human in #Chile a few wks later (3 24, 23) that also has D701N, but this pattern does not hold for trees inferred using other genome segments... these data provide #evidence that D701N is emerging repeatedly in H5N1 viruses that infect mammalian hosts along S America’s Pacific coast... these data cannot yet ascertain if viruses ... are transmitting within mammals.''

Symposium available ahead of print: "The Contribution of #Mutation to #Variation in #TemperatureDependent #SprintSpeed in #Zebrafish, Danio rerio" by Miller et al.

Free Symposium now available ahead of print! "#Mutation and #Selection Induce Correlations between #SelectionCoefficients and #MutationRates" by Bryan L. Gitschlag, Alejandro V. Cano, Joshua L. Payne, David M. McCandlish, and Arlin Stoltzfus

https://www.journals.uchicago.edu/doi/10.1086/726014

"Are mutations random?" is a review of my book by
@Grey_Monroe

He focuses on scrutinizing randomness claims

Other args of interest:

(1) specialized mut systems (e.g., shuffling antigen genes in pathogens) are real (Ch. 5)

2) pop-gen theory today provides for a dispositional influence of variation— via introduction biases— unknown in the 20th century (Ch. 8)

(3) and empirical work shows the predicted dispositional influence of mut bias (Ch. 9)

https://academic.oup.com/evolut/article/doi/10.1093/evolut/qpad152/7252632

#popgen #mutation

Symposium now published ahead of print: "Shifts in #Mutation Bias Promote #Mutators by Altering the Distribution of #Fitness Effects" by Marwa Z. Tuffaha, Saranya Varakunan, David Castellano, Ryan N. Gutenkunst, and Lindi M. Wahl
https://www.journals.uchicago.edu/doi/10.1086/726010#fn1

''Therapeutics: Examination of the #mutation #profile of #BA286 suggests that currently available treatments like #Paxlovid, #Veklury, and #Lagevrio will be effective against this variant. Monitoring is ongoing and CDC will update this document as human data on the impact of this variant on therapeutics become available.''

#Research is under way to determine whether the #mutation-laden #lineage {of #SARS_CoV_2} #BA286 is nothing to worry about — or has the potential to spread globally, Nature: doi: https://doi.org/10.1038/d41586-023-02656-9 #pandemic #covid19 #VOI #surveillance #news

These Bizarre Amphibians Changed The Chemical Landscape To Survive A Plague Of Snakes | @UQ_News @VUBrussel @IJMS_MDPI

This evolutionary drama highlights the intimate yet powerful effects of a transformative arms race between predator and prey

by @GrrlScientist via @ForbesScience / @Forbes

#amphibians #snakes #venom #mutation #evolution https://www.forbes.com/sites/grrlscientist/2023/07/25/these-bizarre-amphibians-changed-the-chemical-landscape-to-survive-a-plague-of-snakes/

It's a land of opportunity!
My uncle was the first to crawl out of the sea, a mutation, with legs instead of fins.
#ScifiFri #mutation

Since I‘ve been reading that politicians in the US have called #trans people „mutants“, I feel the need to point out that this may not be the slur you think it is.

Me, for example, I am 100% that X Men kid who sprouts wings.

Also voice #mutation duuude I can sing „Ring of Fire“ now what‘s there not to totally love and embrace?

#transjoy #gendereuphoria #mutateaway

From cross to self-#pollination: Examining how #plants develop different routes to replication.

#S_allele #gene #modifier #mutation

https://phys.org/news/2023-06-self-pollination-routes-replication.html

#Yeast screen uncovers #genes involved in #chromosomal #mutation.

#Srr1 #Skb1

https://phys.org/news/2023-05-yeast-screen-uncovers-genes-involved.html

Mysteries of the #poisonous #amphibians. How do frogs and other amphibians survive their own noxious weapons?

#epibatidine #neurotransmitter #receptor #mutation #evolution

https://arstechnica.com/science/2023/04/mysteries-of-the-poisonous-amphibians/

Atlas menschlicher Gen-Mutationen. Bisher umfassendster Überblick über Genveränderungen im Laufe unseres Lebens. #Mutation #Genom #Genmutation #Genetik
https://www.scinexx.de/news/medizin/atlas-menschlicher-gen-mutationen/

Another important point: GPT is probabilistic. It chooses words randomly according to a probability distribution. It can generate new code that doesn't exactly match the last iteration. In biological terms, this is #mutation. Not old school computer virus "mutation" where the same code is obfuscated in a zillion different ways. Genuine biology-style mutation where the new code is different from the old code.

Where there is reproduction and mutation, there is evolution. And evolution is, fundamentally, a learning algorithm -- the original grandmomma of them all. The same one that produced us.

Male #beetles neglect their #genomes when competing for females.

#DNA #mutation #evolution

https://phys.org/news/2023-04-male-beetles-neglect-genomes-females.html

Was sind wichtige Testszenarien, die speziell für Universal Windows Platform (UWP)-Anwendungen gelten?
Universal Windows Platform-Apps sind in Gerätefamilien gruppiert, die euch helfen, eine einzige App zu erstellen, die auf je
https://www.dev-crowd.com/2023/03/10/was-sind-wichtige-testszenarien-die-speziell-fuer-universal-windows-platform-uwp-anwendungen-gelten/
#Agile #Mocking #Mutation-Testing #Penetrationtest #RestAPI #TestEngineering #Testlink #Testsuites #UWD #Regressionstest #uwd

Researchers identify #gene #mutation capable of #regulating pain.

https://phys.org/news/2023-03-gene-mutation-capable-pain.html

#Zoonotic #Mutation of Highly Pathogenic #Avian #Influenza #H5N1 Virus Identified in the #Brain of Multiple Wild #Carnivore #Species https://pubmed.ncbi.nlm.nih.gov/36839440/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20230225124534&v=2.17.9.post6+86293ac

#Deer protected from deadly #disease by newly discovered #genetic differences

#EHD #epizootic #TLR3 #dsRNA #virus #mutation #evolution

https://phys.org/news/2023-02-deer-deadly-disease-newly-genetic.html