Episode 5 of the Cell Therapy Podcast is out, this time about NK cells cells: How do they function and can we utilize them as a cellular therapy?
In this episode we are joined by Dr Arnika Wagner & Dr Evren Alici both from the Karolinska Institutet and Dr Sigrid Skånland from Olso University Hospital for a chat about these exciting cells and how their anti-cancer effects are explored - and they can be used in the future.
Check it out: https://open.spotify.com/episode/5KPP7aUbRf75ewSijrUBsY?si=IIHr4vd7T428DyPII93Mng
'Here, Thacker et al. demonstrated that Socs3highCD11b–CD27– immature NK cells were present in samples from patients with triple negative breast cancer (TNBC) and correlated with worse prognosis. The authors further showed that this population of NK cells promoted, rather than inhibited, tumor progression in mice.'
#BreastCancer #NaturalKillerCells #NKcells
https://www.science.org/doi/10.1126/scitranslmed.abl4414#sec-2
#naturalkillercells #breastcancer #NKcells
#pandemic2020 #SARSCoV2 #CoronaVirusUpdates #SARSCoV2virus #Corona #pandemia #pandemia2020 #ash2023 #healthinequity #healthcareinequity #medicine #oncology #celltherapy #immunotherapy #cartcell #cartcells #nkcells #genetherapy #stemcelltherapy #cartcellrx #multiplemyeloma #plasmadiseases
#pandemic2020 #SarsCoV2 #CoronavirusUpdates #sarscov2virus #corona #pandemia #pandemia2020 #ash2023 #healthinequity #healthcareinequity #medicine #oncology #CellTherapy #Immunotherapy #CARTCell #CARTCells #NKcells #genetherapy #stemcelltherapy #cartcellrx #MultipleMyeloma #plasmadiseases
RT @VZBittencourt
Impact of butyrate on NK cells function and metabolism is finally out! Data from my postdoc 😍 🌈🥳 thanks @Elizabe28913853 for all the support ❤️
#nkcells #butyrate #immunometabolism #guthealth https://www.nature.com/articles/s41598-023-29731-5
#NKcells #butyrate #immunometabolism #guthealth
#Innate and #Adaptive #Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms
#COVID19 #Bcells #neutrophils #dendritic_cells #Tcells #NKcells #monocytes #macrophages #SARSCoV2
https://www.mdpi.com/2076-393X/11/2/408
#innate #adaptive #immunity #COVID19 #Bcells #Neutrophils #dendritic_cells #Tcells #NKcells #monocytes #macrophages #SarsCoV2
"Here, we have identified a population of innate lymphocytes that we term tissue-resident memory-like natural killer (NKRM) cells. In response to murine cytomegalovirus infection, we show that circulating NK cells were recruited in a CX3CR1-dependent manner to the salivary glands where they formed NKRM cells, a long-lived, tissue-resident population that prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells."
Schuster et al @ImmunityCP
#Immunology #NKCells #ImmuneRegulation
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
#NKcells #ImmuneRegulation #immunology
#innateimmunity alone is able to induce #tumor regression in an experimental #model of #glioblastoma : intravenous TLR7/8-agonist-loaded #nanoparticles lead to #Tcell -independent eradication of tumor cells. #macrophages #immunology // orchestrated tumor clearing through pro-inflammatory activation of tumor-associated myeloid cells, independent of T cells and #NKcells .
https://www.nature.com/articles/s41467-023-36321-6
#innateimmunity #tumor #model #glioblastoma #nanoparticles #Tcell #macrophages #immunology #NKcells
@ImmunologyKing is there another #infection which does not lead to influx/generation of this type of #NKcells ?
Protecting #tissues from #autoimmunity is a fascinating function of the immune system: in this new work on #innateimmunity in the salivary gland it is #lymphoid #NKcells that regulate #TCells and prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells. These NK cells show adaptive-like features with long-term residency in non-lymphoid tissues. #immunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
#tissues #autoimmunity #innateimmunity #lymphoid #NKcells #TCells #immunology
Powerful debate between William Ho (In8 bio) and Kanya Rajangam (Senti Biosciences). Evenly matched with different styles. we all walked away a bit smarter. #io360nyc no holds barred. That's what makes the Debate Format special.
#cancer #immunotherapy #NKcells #gammadeltaTcells
#io360nyc #cancer #Immunotherapy #NKcells #gammadeltatcells
Congratulations to our very own, Dr. Can Sungur on his publication in the Journal of Clinical Investigation!!! 🎉🎉🎉
Also featured, Dr. Wayne Yokoyama, Rheumatologist and director of the Washington University Division of Physician Scientists! 🎉🎉🎉
To read the full paper, visit https://www.jci.org/articles/view/162694
#Science #physicianscientist #NKcells #washurheum
The collection of immune cell proteomes is really growing at http://ImmPRes.co.uk. Simply fantastic resource.
#Tcells (of many types)
#NKcells
#Neutrophils
#Macrophage
#Bcells
#Basophils
#TheListGoesOn
I know for a fact there’s lots of new datasets on the way too 😁
---
RT @ImmPRes_
we have now added our first #neutrophil dataset to ImmPRes. What effect does hypoxia have on neutrophils when they're activated with LPS? and what happens …
https://twitter.com/ImmPRes_/status/1610671220810203137
#bcells #basophils #TheListGoesOn #neutrophil #tcells #NKcells #Neutrophils #macrophage
#safety #celltherapy #celltherapies #immunotherapy #genetherapy #cellulartherapeutics #IO #cancer #oncology #dlbcl #lymphoma #cartecells #cartcellrx #nkcells #nkcars #bispecifics #tcellengagers #bloodcancers #lymphoma #multiplemyeloma #solidtumors #Breastcancer #GIcancer #cartcell #cartcells #cartcellrx #msc #mesenchymalstemcells #mesenchymalstemcell #CRISPR #crisprcas9 #genetherapy #geneediting #checkpointinhibitors #bmt #bmtrx #bmtsm #tcellrx
#safety #CellTherapy #celltherapies #Immunotherapy #genetherapy #cellulartherapeutics #IO #cancer #oncology #dlbcl #lymphoma #cartecells #cartcellrx #NKcells #nkcars #bispecifics #tcellengagers #BloodCancers #MultipleMyeloma #solidtumors #breastcancer #gicancer #CARTCell #CARTCells #msc #mesenchymalstemcells #mesenchymalstemcell #crispr #crisprcas9 #geneediting #checkpointinhibitors #BMT #bmtrx #bmtsm #tcellrx
tho always weird to give a seminar to myself, it's done! have a listen here if you like: https://youtu.be/i0GAhB3a2F8
the 2nd half is *unpublished* data on #tissue #CD4 #Tcells during #influenza and how they fit into a network of #CD8 #Bcells, #IgA & #NKcells.
I've received feedback from someone working on tumors that some of it brings new perspective on his data. In return I learned some new stuff about bladder cancer.
This open exchange of ideas is why I'm a scientist.
#tissue #cd4 #TCells #influenza #cd8 #Bcells #IgA #NKcells
Our new review of engineering NK cells for cancer immunotherapy
@BiologyOpen@twitter.com
@Co_Biologists@twitter.com
#immunotherapy #NKcells #CARNK
https://journals.biologists.com/bio/article/11/12/bio059396/284640/The-prospect-of-genetically-engineering-natural
#Immunotherapy #NKcells #carnk
RT @immunonoah@twitter.com
😃Really happy to see our manuscript, from the McKenzie Lab, @MRC_LMB@twitter.com, finally out in @PNASNews@twitter.com!!
We went looking for NK cell progenitors (NKP) within ILC progenitors (ILCP) in mouse bone marrow (BM). #NKcells
🧵👇 1/
https://www.pnas.org/doi/10.1073/pnas.2203454119
🐦🔗: https://twitter.com/immunonoah/status/1598212754439286785
We're up next for #globalimmuno talk this Wednesday, November 30th at 9am PST, noon EST, 5pm GMT. It says #Tcells but there will be some #Bcells and #NKcells too!
Title: "CD4 T cells Sans Frontières"
LINK: ucsd.zoom.us/j/91053505061
#globalimmuno #TCells #Bcells #NKcells
Hey there! I'm an Assistant Professor at #UCLA studying mouse and human #innateimmunity using #systemsimmunology and #crispr to find new targets for chronic viral infections, #T2D and #cancer. I mainly focus on #type1 immune responses including #NKcells #cDC1 and #ILC1. I started #earlycareerimmunology in 2021 to highlight underrepresented scientists early in their career. I'm here to post about #science, #art, #travel, #cat photos, and congratulate you on your wins 🥳🎉.
#ucla #innateimmunity #systemsimmunology #crispr #T2D #cancer #Type1 #NKcells #cdc1 #ilc1 #earlycareerimmunology #Science #art #travel #cat
Immunologist and cell biologist based in the San Francisco Bay Area, California. Discovery researcher in #celltherapy for #autoimmune diseases. Subject matter expert #NKcells and #allogeneic therapies.
Additional interests spanning from #virology to #artscience #cosmology #archeology #history #paleontology #climatechange
Excited to join this network!
#introduction #CellTherapy #autoimmune #NKcells #allogeneic #virology #artscience #cosmology #archeology #history #paleontology #climatechange