In a paper now out in Angewandte, we have applied directed evolution on the nonribosomal peptide synthetase (#NRPS) making the peptide #antibiotic gramicidin S. Just a few mutations were sufficient to make the NRPS incorporate the non-standard building block piperazic acid instead of proline into the peptide. Directed evolution of NRPSs is needed to adapt the structures of antibiotic peptides to help fight increasing #AntimicrobialResistance.

https://doi.org/10.1002/anie.202304843

@LeibnizHKI

Baukultur, biodiversity, gender medicine and plant breeding: at year-end 2023 we will open calls for four new National #Research Programmes #NRPs launched by the Federal Council. Learn more about the focus areas now.
https://sohub.io/w5y9

:100a: followers on #mastodon ! I love the fact that you can gather so many people interested in #NRPS, #NaturalProducts and the like in no time. And this is just the beginning. Still wish #Leibniz had their own instance... I'll ask Santa.

It's time for a decent scientific social network! #Mastodon looks great and we will be spreading our thoughts on #NRPS here.

It's time for a decent scientific social network! #Mastodon looks great and we will be spreading our thoughts on #NRPS here.