Javier Díaz-Nido · @Javier_DN
173 followers · 361 posts · Server red.niboe.infoImpact of social isolation on grey matter structure and cognitive functions: A population-based longitudinal neuroimaging study
Social isolation contributes to human brain atrophy and cognitive decline, indicating an opportunity to reduce dementia risk by promoting social networks.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer
#CognitiveDecline #CognitiveDysfunction #Dementia #Hippocampus #Neuroimaging #NeuroImage #SocialIsolation #SocialBond
#Biomedicine #Health
#health #biomedicine #SocialBond #SocialIsolation #NeuroImage #neuroimaging #hippocampus #dementia #CognitiveDysfunction #CognitiveDecline #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
173 followers · 360 posts · Server red.niboe.infoSocial Bonds Protect Aging Brains
Social isolation can potentially harm brain structure and cognitive performance, suggesting an increased risk of conditions like Alzheimer’s dementia.
A lack of quality social interaction can lead to a decrease in the hippocampus’s volume, crucial for memory formation and retrieval, and poorer cognitive performance.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer
#CognitiveDecline #CognitiveDysfunction #Dementia #Hippocampus #Neuroimaging #NeuroImage #SocialIsolation #SocialBond
#Biomedicine #Health
https://neurosciencenews.com/social-aging-neuroscience-brain-23505/
#health #biomedicine #SocialBond #SocialIsolation #NeuroImage #neuroimaging #hippocampus #dementia #CognitiveDysfunction #CognitiveDecline #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
171 followers · 359 posts · Server red.niboe.infoAstrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
Aβ was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast+).
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #BetaAmyloid #AmyloidPlaques #Tau #NeurofibrillaryTangles #ReactiveAstrocytes #Astrocytes #Glia #GFAP #Biomarker #Alzheimer #Biomedicine #Health
#health #biomedicine #Alzheimer #Biomarker #GFAP #Glia #astrocytes #ReactiveAstrocytes #NeurofibrillaryTangles #Tau #AmyloidPlaques #BetaAmyloid #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
171 followers · 356 posts · Server red.niboe.infoFunctional roles of reactive astrocytes in neuroinflammation and neurodegeneration
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Neuroimmunology #Neuroimmune #ReactiveAstrocytes #Astrocytes #Glia #Alzheimer #Parkinson #Biomedicine #Health
#health #biomedicine #parkinson #Alzheimer #Glia #astrocytes #ReactiveAstrocytes #Neuroimmune #neuroimmunology #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
171 followers · 354 posts · Server red.niboe.infoTherapeutic Strategies for Spinocerebellar Ataxia Type 1 (SCA1)
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #SpinocerebellarAtaxia #SCA1 #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#Biomedicine #Health
#health #biomedicine #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #SCA1 #SpinocerebellarAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
170 followers · 351 posts · Server red.niboe.infoMultifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases.
Friedreich’s ataxia represents a test case to validate the potential of therapeutic strategies based on nanoparticles.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#GeneTherapy
#Neuroinflammation
#Mitochondria #MitochondrialDysfunction
#Nanoparticles #Nanomedicine #Nanobiotechnology
#Biomedicine #Health
https://academic.oup.com/brain/article/doi/10.1093/brain/awad014/7024724
#health #biomedicine #Nanobiotechnology #Nanomedicine #nanoparticles #MitochondrialDysfunction #mitochondria #neuroinflammation #genetherapy #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
170 followers · 349 posts · Server red.niboe.infoAPOE expression and secretion are modulated by mitochondrial dysfunction
This study presents compelling evidence that ApoE is upregulated in various models of mitochondrial respiratory chain dysfunction. The work is of fundamental interest for those studying neurodegeneration and the role of ApoE in Alzheimer's disease; future work will be needed to reveal the molecular basis of this dramatic phenotype.
#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #ApoE #Neurogenetics #Mitochondria #MitochondrialDysfunction
#MitochondrialDysfunction #mitochondria #neurogenetics #ApoE #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience #biomedicine
Javier Díaz-Nido · @Javier_DN
169 followers · 342 posts · Server red.niboe.infoVatiquinone found to slow Friedreich's Ataxia progression by 75% after 1.5 years
But oral therapy fails to meet primary goal in Phase 2/3 trial
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#Vatiquinone #Neuroinflammation
#Biomedicine #Health
https://friedreichsataxianews.com/news/vatiquinone-slows-fa-progression-after-18-months-trial-data/
#health #biomedicine #neuroinflammation #Vatiquinone #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
169 followers · 338 posts · Server red.niboe.infoRunning throughout Middle-Age Keeps Old Adult-Born Neurons Wired
Long-term running maintains the wiring of “old” new neurons, born during early adulthood, within a network that is important for memory function during aging in mice.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
#running #PhysicalExercise #physicalactivity #CognitiveDysfunction #CognitiveDecline #memoryLoss #aging #BrainAging #neuron #neurogenesis #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
169 followers · 337 posts · Server red.niboe.infoRunning Rewires the Aging Brain: Exercise Protects Memory Function
Physical activity, particularly running, has been found to rewire aging brains, helping to preserve memory functions.
Long-term running keeps older neurons wired, potentially preventing age-related memory loss and neurodegeneration.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
https://neurosciencenews.com/running-neurogenesis-aging-23339/
#running #PhysicalExercise #physicalactivity #CognitiveDysfunction #CognitiveDecline #memoryLoss #aging #BrainAging #neuron #neurogenesis #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
169 followers · 330 posts · Server red.niboe.infoShort-read genome sequencing test may help diagnose atypical Friedreich's Ataxia
Test advised for patients whose symptoms, family history are not indicative of Friedreich's Ataxia.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
169 followers · 267 posts · Server red.niboe.infoNew Friedreich's Ataxia mouse model may aid research, therapy development
Mice house largest reported number of GAA repeats in Frataxin gene
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenetics #NeurogeneticDiseases #GeneticDiseases #RareDiseases #Ataxia #FriedreichAtaxia #Frataxin
https://friedreichsataxianews.com/news/new-fa-mouse-model-may-aid-research-therapy-development/
#Frataxin #FriedreichAtaxia #ataxia #RareDiseases #GeneticDiseases #NeurogeneticDiseases #neurogenetics #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
167 followers · 259 posts · Server red.niboe.infoPeripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Inflammation #ImmuneResponse #Parkinson
#parkinson #ImmuneResponse #inflammation #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
166 followers · 251 posts · Server red.niboe.infoImaging Study Implicates Reactive Astrocyte-Neuron Interaction in Alzheimer’s Cognitive Decline
PET imaging with 11C-acetate and 18F-FDG was used to visualize the reactive astrocyte-induced acetate hypermetabolism and associated neuronal glucose hypometabolism in brains with neuroinflammation and Alzheimer’s Disease.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #BrainImaging #Neuroimaging #NeuroMetabolism #AcetateHypermetabolism #GlucoseHypometabolism #NeuroInflammation #CognitiveDecline #CognitiveDysfunction
#CognitiveDysfunction #CognitiveDecline #neuroinflammation #GlucoseHypometabolism #AcetateHypermetabolism #NeuroMetabolism #neuroimaging #BrainImaging #Alzheimer #neuron #astrocyte #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
166 followers · 250 posts · Server red.niboe.infoAutophagy in Spinocerebellar Ataxia Type 3: From Pathogenesis to Therapeutics
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Ataxia #SpinocerebellarAtaxia #SCA3 #MachadoJosephDisease #Neuroprotection #Neuropharmacology #Neurotherapeutics #Autophagy
#autophagy #neurotherapeutics #Neuropharmacology #neuroprotection #MachadoJosephDisease #SCA3 #SpinocerebellarAtaxia #ataxia #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
166 followers · 246 posts · Server red.niboe.infoMusic interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy
#Neuroscience #Brain #Cerebellum #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #BrainAging #Aging #CognitiveDecline #BrainAtrophy #Music
https://www.sciencedirect.com/science/article/pii/S2666956023000119
#music #BrainAtrophy #CognitiveDecline #aging #BrainAging #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #Cerebellum #brain #neuroscience
Javier Díaz-Nido · @Javier_DN
166 followers · 245 posts · Server red.niboe.infoHow Music Can Prevent Cognitive Decline
Listening to or practicing music had positive implications on cognitive decline in older adults by stimulating the production of gray matter in key brain areas including the cerebellum, a new study reveals.
#Neuroscience #Brain #Cerebellum #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #BrainAging #Aging #CognitiveDecline #BrainAtrophy #Music
#music #BrainAtrophy #CognitiveDecline #aging #BrainAging #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #Cerebellum #brain #neuroscience
Phys.org · @physorg_bot
428 followers · 10512 posts · Server social.platypush.techReferenced link: https://medicalxpress.com/news/2023-03-pruning-neurodegeneration-brain.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-pruning-neurodegeneration-brain.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1638990520365252608#m
RT by @physorg_com: Too much pruning: A new study sheds light on how #neurodegeneration occurs in the #brain @CellCellPress https://linkinghub.elsevier.com/retrieve/pii/S0092867423001666 https://medicalxpress.com/news/2023-03-pruning-neurodegeneration-brain.html
Javier Díaz-Nido · @Javier_DN
161 followers · 215 posts · Server red.niboe.infoFresh Understanding of Aging in the Brain Offers Hope for Treating Neurological Diseases
As the brain ages, microglia adopt dysfunctional states that increase the risk of developing neurodegenerative diseases such as Alzheimer’s disease.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Alzheimer #Neurodegeneration #Neuroinflammation #Microglia #BrainAging #Aging
#aging #BrainAging #microglia #neuroinflammation #Neurodegeneration #Alzheimer #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Penn NeuroKnow · @pennNeuroKnow
142 followers · 32 posts · Server qoto.org
🧠 This week co-editor @Catrina_Hacker writes about a new study that looked at the association between viral infection and neurodegenerative diseases in her post titled, "Growing evidence for a link between viral infections and brain diseases".
😷 This is a follow-up to her previous post about the commonalities between COVID-19 infection and Alzheimer's disease. This week's post breaks down a recent study that found links between several viral infections and neurodegenerative diseases. Catrina discusses what this study does and does not tell us about this possible connection.
Read this week's post here: https://pennneuroknow.com/2023/02/07/growing-evidence-for-a-link-between-viral-infections-and-brain-diseases/
And the original post here: https://pennneuroknow.com/2022/02/01/what-covid-19-has-to-tell-us-about-alzheimers-disease%ef%bf%bc/
#neuroscience #brain #scicomm #neurodegeneration #virus #science
#neuroscience #brain #scicomm #virus #science #Neurodegeneration