Impact of social isolation on grey matter structure and cognitive functions: A population-based longitudinal neuroimaging study
Social isolation contributes to human brain atrophy and cognitive decline, indicating an opportunity to reduce dementia risk by promoting social networks.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer
#CognitiveDecline #CognitiveDysfunction #Dementia #Hippocampus #Neuroimaging #NeuroImage #SocialIsolation #SocialBond
#Biomedicine #Health
#health #biomedicine #SocialBond #SocialIsolation #NeuroImage #neuroimaging #hippocampus #dementia #CognitiveDysfunction #CognitiveDecline #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Social Bonds Protect Aging Brains
Social isolation can potentially harm brain structure and cognitive performance, suggesting an increased risk of conditions like Alzheimer’s dementia.
A lack of quality social interaction can lead to a decrease in the hippocampus’s volume, crucial for memory formation and retrieval, and poorer cognitive performance.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer
#CognitiveDecline #CognitiveDysfunction #Dementia #Hippocampus #Neuroimaging #NeuroImage #SocialIsolation #SocialBond
#Biomedicine #Health
https://neurosciencenews.com/social-aging-neuroscience-brain-23505/
#health #biomedicine #SocialBond #SocialIsolation #NeuroImage #neuroimaging #hippocampus #dementia #CognitiveDysfunction #CognitiveDecline #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
Aβ was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast+).
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #BetaAmyloid #AmyloidPlaques #Tau #NeurofibrillaryTangles #ReactiveAstrocytes #Astrocytes #Glia #GFAP #Biomarker #Alzheimer #Biomedicine #Health
#health #biomedicine #Alzheimer #Biomarker #GFAP #Glia #astrocytes #ReactiveAstrocytes #NeurofibrillaryTangles #Tau #AmyloidPlaques #BetaAmyloid #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Neuroimmunology #Neuroimmune #ReactiveAstrocytes #Astrocytes #Glia #Alzheimer #Parkinson #Biomedicine #Health
#health #biomedicine #parkinson #Alzheimer #Glia #astrocytes #ReactiveAstrocytes #Neuroimmune #neuroimmunology #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Therapeutic Strategies for Spinocerebellar Ataxia Type 1 (SCA1)
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #SpinocerebellarAtaxia #SCA1 #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#Biomedicine #Health
#health #biomedicine #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #SCA1 #SpinocerebellarAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases.
Friedreich’s ataxia represents a test case to validate the potential of therapeutic strategies based on nanoparticles.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#GeneTherapy
#Neuroinflammation
#Mitochondria #MitochondrialDysfunction
#Nanoparticles #Nanomedicine #Nanobiotechnology
#Biomedicine #Health
https://academic.oup.com/brain/article/doi/10.1093/brain/awad014/7024724
#health #biomedicine #Nanobiotechnology #Nanomedicine #nanoparticles #MitochondrialDysfunction #mitochondria #neuroinflammation #genetherapy #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
APOE expression and secretion are modulated by mitochondrial dysfunction
This study presents compelling evidence that ApoE is upregulated in various models of mitochondrial respiratory chain dysfunction. The work is of fundamental interest for those studying neurodegeneration and the role of ApoE in Alzheimer's disease; future work will be needed to reveal the molecular basis of this dramatic phenotype.
#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #ApoE #Neurogenetics #Mitochondria #MitochondrialDysfunction
#MitochondrialDysfunction #mitochondria #neurogenetics #ApoE #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience #biomedicine
Vatiquinone found to slow Friedreich's Ataxia progression by 75% after 1.5 years
But oral therapy fails to meet primary goal in Phase 2/3 trial
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#Vatiquinone #Neuroinflammation
#Biomedicine #Health
https://friedreichsataxianews.com/news/vatiquinone-slows-fa-progression-after-18-months-trial-data/
#health #biomedicine #neuroinflammation #Vatiquinone #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Running throughout Middle-Age Keeps Old Adult-Born Neurons Wired
Long-term running maintains the wiring of “old” new neurons, born during early adulthood, within a network that is important for memory function during aging in mice.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
#running #PhysicalExercise #physicalactivity #CognitiveDysfunction #CognitiveDecline #memoryLoss #aging #BrainAging #neuron #neurogenesis #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Running Rewires the Aging Brain: Exercise Protects Memory Function
Physical activity, particularly running, has been found to rewire aging brains, helping to preserve memory functions.
Long-term running keeps older neurons wired, potentially preventing age-related memory loss and neurodegeneration.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
https://neurosciencenews.com/running-neurogenesis-aging-23339/
#running #PhysicalExercise #physicalactivity #CognitiveDysfunction #CognitiveDecline #memoryLoss #aging #BrainAging #neuron #neurogenesis #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Short-read genome sequencing test may help diagnose atypical Friedreich's Ataxia
Test advised for patients whose symptoms, family history are not indicative of Friedreich's Ataxia.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
New Friedreich's Ataxia mouse model may aid research, therapy development
Mice house largest reported number of GAA repeats in Frataxin gene
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenetics #NeurogeneticDiseases #GeneticDiseases #RareDiseases #Ataxia #FriedreichAtaxia #Frataxin
https://friedreichsataxianews.com/news/new-fa-mouse-model-may-aid-research-therapy-development/
#Frataxin #FriedreichAtaxia #ataxia #RareDiseases #GeneticDiseases #NeurogeneticDiseases #neurogenetics #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Inflammation #ImmuneResponse #Parkinson
#parkinson #ImmuneResponse #inflammation #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Imaging Study Implicates Reactive Astrocyte-Neuron Interaction in Alzheimer’s Cognitive Decline
PET imaging with 11C-acetate and 18F-FDG was used to visualize the reactive astrocyte-induced acetate hypermetabolism and associated neuronal glucose hypometabolism in brains with neuroinflammation and Alzheimer’s Disease.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #BrainImaging #Neuroimaging #NeuroMetabolism #AcetateHypermetabolism #GlucoseHypometabolism #NeuroInflammation #CognitiveDecline #CognitiveDysfunction
#CognitiveDysfunction #CognitiveDecline #neuroinflammation #GlucoseHypometabolism #AcetateHypermetabolism #NeuroMetabolism #neuroimaging #BrainImaging #Alzheimer #neuron #astrocyte #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Autophagy in Spinocerebellar Ataxia Type 3: From Pathogenesis to Therapeutics
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Ataxia #SpinocerebellarAtaxia #SCA3 #MachadoJosephDisease #Neuroprotection #Neuropharmacology #Neurotherapeutics #Autophagy
#autophagy #neurotherapeutics #Neuropharmacology #neuroprotection #MachadoJosephDisease #SCA3 #SpinocerebellarAtaxia #ataxia #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy
#Neuroscience #Brain #Cerebellum #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #BrainAging #Aging #CognitiveDecline #BrainAtrophy #Music
https://www.sciencedirect.com/science/article/pii/S2666956023000119
#music #BrainAtrophy #CognitiveDecline #aging #BrainAging #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #Cerebellum #brain #neuroscience
How Music Can Prevent Cognitive Decline
Listening to or practicing music had positive implications on cognitive decline in older adults by stimulating the production of gray matter in key brain areas including the cerebellum, a new study reveals.
#Neuroscience #Brain #Cerebellum #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #BrainAging #Aging #CognitiveDecline #BrainAtrophy #Music
#music #BrainAtrophy #CognitiveDecline #aging #BrainAging #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #Cerebellum #brain #neuroscience
Referenced link: https://medicalxpress.com/news/2023-03-pruning-neurodegeneration-brain.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-pruning-neurodegeneration-brain.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1638990520365252608#m
RT by @physorg_com: Too much pruning: A new study sheds light on how #neurodegeneration occurs in the #brain @CellCellPress https://linkinghub.elsevier.com/retrieve/pii/S0092867423001666 https://medicalxpress.com/news/2023-03-pruning-neurodegeneration-brain.html
Fresh Understanding of Aging in the Brain Offers Hope for Treating Neurological Diseases
As the brain ages, microglia adopt dysfunctional states that increase the risk of developing neurodegenerative diseases such as Alzheimer’s disease.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Alzheimer #Neurodegeneration #Neuroinflammation #Microglia #BrainAging #Aging
#aging #BrainAging #microglia #neuroinflammation #Neurodegeneration #Alzheimer #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
🧠 This week co-editor @Catrina_Hacker writes about a new study that looked at the association between viral infection and neurodegenerative diseases in her post titled, "Growing evidence for a link between viral infections and brain diseases".
😷 This is a follow-up to her previous post about the commonalities between COVID-19 infection and Alzheimer's disease. This week's post breaks down a recent study that found links between several viral infections and neurodegenerative diseases. Catrina discusses what this study does and does not tell us about this possible connection.
Read this week's post here: https://pennneuroknow.com/2023/02/07/growing-evidence-for-a-link-between-viral-infections-and-brain-diseases/
And the original post here: https://pennneuroknow.com/2022/02/01/what-covid-19-has-to-tell-us-about-alzheimers-disease%ef%bf%bc/
#neuroscience #brain #scicomm #neurodegeneration #virus #science
#neuroscience #brain #scicomm #virus #science #Neurodegeneration