TrangAston :verified: · @CastlTrAstonDrs
1434 followers · 3118 posts · Server med-mastodon.com
@biorxivpreprint
Both these diseases and several other neurodegenerative diseases are caused by conversion of human proteins into a misfolded, aggregated amyloid fibril state. The data suggest that cross-seeding by Spike-amyloid fibrils can be implicated in the increasing number of reports of CJD, AD and possibly other #NeurodegenerativeDiseases in the wake of #omicron Sub Variants
https://www.biorxiv.org/content/10.1101/2023.09.01.555834v1.full.pdf
#NeurodegenerativeDiseases #omicron
TrangAston :verified: · @CastlTrAstonDrs
1433 followers · 3117 posts · Server med-mastodon.com#IDMastodaon #NeuroCovid MedSkyđ§ŞThe more I learned about #SARScoV2đŚ and their destructive doing to the host immunity , the more further distance away that i keep from the crowd & đˇwould never leave my face .Especially in the wakes of Eris and Pirola .#CovidIsNotOver . An increasing number of reports suggest an association between #SarsCoV2 infection and initiation or acceleration of #neurodegenerativediseases ( #Alzheimersdisease & #CreutzfeldtJakobdisease )
#idmastodaon #neurocovid #SarsCoV2 #CovidIsNotOver #NeurodegenerativeDiseases #alzheimersdisease #creutzfeldtjakobdisease
Javier DĂaz-Nido · @Javier_DN
173 followers · 361 posts · Server red.niboe.infoImpact of social isolation on grey matter structure and cognitive functions: A population-based longitudinal neuroimaging study
Social isolation contributes to human brain atrophy and cognitive decline, indicating an opportunity to reduce dementia risk by promoting social networks.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer
#CognitiveDecline #CognitiveDysfunction #Dementia #Hippocampus #Neuroimaging #NeuroImage #SocialIsolation #SocialBond
#Biomedicine #Health
#health #biomedicine #SocialBond #SocialIsolation #NeuroImage #neuroimaging #hippocampus #dementia #CognitiveDysfunction #CognitiveDecline #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
173 followers · 360 posts · Server red.niboe.infoSocial Bonds Protect Aging Brains
Social isolation can potentially harm brain structure and cognitive performance, suggesting an increased risk of conditions like Alzheimerâs dementia.
A lack of quality social interaction can lead to a decrease in the hippocampusâs volume, crucial for memory formation and retrieval, and poorer cognitive performance.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer
#CognitiveDecline #CognitiveDysfunction #Dementia #Hippocampus #Neuroimaging #NeuroImage #SocialIsolation #SocialBond
#Biomedicine #Health
https://neurosciencenews.com/social-aging-neuroscience-brain-23505/
#health #biomedicine #SocialBond #SocialIsolation #NeuroImage #neuroimaging #hippocampus #dementia #CognitiveDysfunction #CognitiveDecline #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
171 followers · 359 posts · Server red.niboe.infoAstrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimerâs disease
Aβ was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast+).
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #BetaAmyloid #AmyloidPlaques #Tau #NeurofibrillaryTangles #ReactiveAstrocytes #Astrocytes #Glia #GFAP #Biomarker #Alzheimer #Biomedicine #Health
#health #biomedicine #Alzheimer #Biomarker #GFAP #Glia #astrocytes #ReactiveAstrocytes #NeurofibrillaryTangles #Tau #AmyloidPlaques #BetaAmyloid #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
171 followers · 356 posts · Server red.niboe.infoFunctional roles of reactive astrocytes in neuroinflammation and neurodegeneration
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Neuroimmunology #Neuroimmune #ReactiveAstrocytes #Astrocytes #Glia #Alzheimer #Parkinson #Biomedicine #Health
#health #biomedicine #parkinson #Alzheimer #Glia #astrocytes #ReactiveAstrocytes #Neuroimmune #neuroimmunology #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
171 followers · 354 posts · Server red.niboe.infoTherapeutic Strategies for Spinocerebellar Ataxia Type 1 (SCA1)
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #SpinocerebellarAtaxia #SCA1 #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#Biomedicine #Health
#health #biomedicine #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #SCA1 #SpinocerebellarAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
170 followers · 351 posts · Server red.niboe.infoMultifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases.
Friedreichâs ataxia represents a test case to validate the potential of therapeutic strategies based on nanoparticles.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#GeneTherapy
#Neuroinflammation
#Mitochondria #MitochondrialDysfunction
#Nanoparticles #Nanomedicine #Nanobiotechnology
#Biomedicine #Health
https://academic.oup.com/brain/article/doi/10.1093/brain/awad014/7024724
#health #biomedicine #Nanobiotechnology #Nanomedicine #nanoparticles #MitochondrialDysfunction #mitochondria #neuroinflammation #genetherapy #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
170 followers · 349 posts · Server red.niboe.infoAPOE expression and secretion are modulated by mitochondrial dysfunction
This study presents compelling evidence that ApoE is upregulated in various models of mitochondrial respiratory chain dysfunction. The work is of fundamental interest for those studying neurodegeneration and the role of ApoE in Alzheimer's disease; future work will be needed to reveal the molecular basis of this dramatic phenotype.
#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #ApoE #Neurogenetics #Mitochondria #MitochondrialDysfunction
#MitochondrialDysfunction #mitochondria #neurogenetics #ApoE #Alzheimer #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience #biomedicine
Javier DĂaz-Nido · @Javier_DN
169 followers · 342 posts · Server red.niboe.infoVatiquinone found to slow Friedreich's Ataxia progression by 75% after 1.5 years
But oral therapy fails to meet primary goal in Phase 2/3 trial
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#Genetics #HereditaryDiseases #GeneticDiseases
#ClinicalTrial
#Vatiquinone #Neuroinflammation
#Biomedicine #Health
https://friedreichsataxianews.com/news/vatiquinone-slows-fa-progression-after-18-months-trial-data/
#health #biomedicine #neuroinflammation #Vatiquinone #ClinicalTrial #GeneticDiseases #HereditaryDiseases #genetics #neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
169 followers · 338 posts · Server red.niboe.infoRunning throughout Middle-Age Keeps Old Adult-Born Neurons Wired
Long-term running maintains the wiring of âoldâ new neurons, born during early adulthood, within a network that is important for memory function during aging in mice.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
#running #PhysicalExercise #physicalactivity #CognitiveDysfunction #CognitiveDecline #memoryLoss #aging #BrainAging #neuron #neurogenesis #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
169 followers · 337 posts · Server red.niboe.infoRunning Rewires the Aging Brain: Exercise Protects Memory Function
Physical activity, particularly running, has been found to rewire aging brains, helping to preserve memory functions.
Long-term running keeps older neurons wired, potentially preventing age-related memory loss and neurodegeneration.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
https://neurosciencenews.com/running-neurogenesis-aging-23339/
#running #PhysicalExercise #physicalactivity #CognitiveDysfunction #CognitiveDecline #memoryLoss #aging #BrainAging #neuron #neurogenesis #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
169 followers · 330 posts · Server red.niboe.infoShort-read genome sequencing test may help diagnose atypical Friedreich's Ataxia
Test advised for patients whose symptoms, family history are not indicative of Friedreich's Ataxia.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
#neurogenetics #NeurogeneticDiseases #Ataxias #HereditaryAtaxias #FriedreichAtaxia #ataxia #Cerebellum #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
169 followers · 267 posts · Server red.niboe.infoNew Friedreich's Ataxia mouse model may aid research, therapy development
Mice house largest reported number of GAA repeats in Frataxin gene
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenetics #NeurogeneticDiseases #GeneticDiseases #RareDiseases #Ataxia #FriedreichAtaxia #Frataxin
https://friedreichsataxianews.com/news/new-fa-mouse-model-may-aid-research-therapy-development/
#Frataxin #FriedreichAtaxia #ataxia #RareDiseases #GeneticDiseases #NeurogeneticDiseases #neurogenetics #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
169 followers · 261 posts · Server red.niboe.infoCognitive Decline May Be Triggered by Astrocyte Dysfunction
A new study reveals astrocyte dysfunction may be a driver of cognitive decline and memory loss in those with dementia. This may be caused by a protein build-up in the astrocytes that appears to trigger abnormal antiviral activity that results in memory loss.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Astrocytes #AstrocyteDysfunction #BrainAging #MemoryLoss #CognitiveDecline #Dementia #Alzheimer
https://neurosciencenews.com/cognitive-decline-astrocytes-23063/
#Alzheimer #dementia #CognitiveDecline #memoryLoss #BrainAging #AstrocyteDysfunction #astrocytes #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
167 followers · 259 posts · Server red.niboe.infoPeripheral inflammatory immune response differs among sporadic and familial Parkinsonâs disease
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Inflammation #ImmuneResponse #Parkinson
#parkinson #ImmuneResponse #inflammation #neuroinflammation #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
167 followers · 256 posts · Server red.niboe.infoBBB opening with focused ultrasound in nonhuman primates and Parkinsonâs disease patients:
Targeted AAV vector delivery and PET imaging
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #BoodBrainBarrier #BBB #BBBopening #FocusedUltrasound #GeneTherapy #AAV #AAVvector #ViralVector #Parkinson #Neuroimaging #PET
#pet #neuroimaging #parkinson #ViralVector #AAVvector #AAV #genetherapy #FocusedUltrasound #BBBopening #bbb #BoodBrainBarrier #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
166 followers · 251 posts · Server red.niboe.infoImaging Study Implicates Reactive Astrocyte-Neuron Interaction in Alzheimerâs Cognitive Decline
PET imaging with 11C-acetate and 18F-FDG was used to visualize the reactive astrocyte-induced acetate hypermetabolism and associated neuronal glucose hypometabolism in brains with neuroinflammation and Alzheimerâs Disease.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #BrainImaging #Neuroimaging #NeuroMetabolism #AcetateHypermetabolism #GlucoseHypometabolism #NeuroInflammation #CognitiveDecline #CognitiveDysfunction
#CognitiveDysfunction #CognitiveDecline #neuroinflammation #GlucoseHypometabolism #AcetateHypermetabolism #NeuroMetabolism #neuroimaging #BrainImaging #Alzheimer #neuron #astrocyte #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
166 followers · 250 posts · Server red.niboe.infoAutophagy in Spinocerebellar Ataxia Type 3: From Pathogenesis to Therapeutics
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Ataxia #SpinocerebellarAtaxia #SCA3 #MachadoJosephDisease #Neuroprotection #Neuropharmacology #Neurotherapeutics #Autophagy
#autophagy #neurotherapeutics #Neuropharmacology #neuroprotection #MachadoJosephDisease #SCA3 #SpinocerebellarAtaxia #ataxia #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #brain #neuroscience
Javier DĂaz-Nido · @Javier_DN
166 followers · 246 posts · Server red.niboe.infoMusic interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy
#Neuroscience #Brain #Cerebellum #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #BrainAging #Aging #CognitiveDecline #BrainAtrophy #Music
https://www.sciencedirect.com/science/article/pii/S2666956023000119
#music #BrainAtrophy #CognitiveDecline #aging #BrainAging #Neurodegeneration #NeurodegenerativeDiseases #NeurologicalDiseases #neurology #Cerebellum #brain #neuroscience