Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510

Tatsuki Tsuruoka, Kazuyasu Sakaguchi, Toshiaki Imagawa and colleagues share their reporter system for visualising transcriptional activity of p53 at the single cell level.

https://journals.biologists.com/jcs/article/136/12/jcs260918/316739/Development-of-a-fluorescence-reporter-system-to

#cellbiology #p53

TIL (from #ChatGPT 's imagination) that one of our people at @GordianBio discovered the importance of #p53 and is moonlighting as a #Caltech professor 🤣

In single pancreatic cells responding to oxidative stress, JNK dynamics regulate an early trigger of cell death, #p53 controls late maintenance of cell cycle arrest &p38 controls a switch between JNK- and p53-dependent cell fate➡️ http://bit.ly/3UPf6YM E Batchelor (UMN Medical School) #QBio #cellfate #SystemsBiology

Hi #ScienceMastodon - my lab's most recent findings just hit preprint here: https://www.sciencedirect.com/science/article/pii/S0022202X22018887?via%3Dihub

We discovered a #mousemodel for examining #cSCC where #mice with epidermal deficiency of #KDM6A and #P53 show 100% penetrant, spontaneous cSCC development within a year!

#dermatology and #skincancer have very few models to study cSCC in mice and our lab found one!

#cancer #epigenetics #academicchatter #derm #tumorsuppressors #tumor #scicomm