🧩#ZeroPMPieces #12:
How can you avoid #animaltesting when assessing the #toxicity of #PFAS and #PMT substances?

Watch Sylvia Escher from
@Fraunhofer ITEM
explain #PBPK modelling and new approach methodologies (#NAMs)

https://youtu.be/Zim_Y8Psrfc

🧠🫀 🫁

Physiologically-based PK (#PBPK) models, for example, find the middle ground between PK and #QSP, having a more mechanistic bent by taking into account anatomical, physiological, physical, and chemical descriptions of the phenomena involved in complex absorption, distribution, metabolic and elimination (#ADME) processes, while remaining fundamentally driven by observed data.