Subcutaneously administered #antibiotics: a review

via Journal of Antimicrobial Chemotherapy

#PKPD

https://academic.oup.com/jac/article-abstract/78/1/1/6827323

I'm cursing more than I would like to on my first day trying #Pumas for #PKPD modelling in @julialang.
I do understand that they want to make money with it but, damn, this should be easier. So, here's a little 🧵 on why I'm cursing this much.

#introduction 👋

I am a French 🇨🇦 clinical #criticalcare #pharmacist from Montreal with interest in #sedation #analgesia #delirium #hemodynamic #pkpd #teamwork

I am co-founder of the French Critical Care podcast FrancoFOAM https://francofoam.com/ & I'm part of the amazing team of EZDrips https://www.ezdrips.com/ a drug administration facilitating app.

Here to continue learning on critical care & other stuff !

Slowly turning orange! Preparing for a series of #hollowfiber experiments of clofazimine containing #antibiotic regimens for #ntmlungdisease. Great work by Sandra Salillas and Jelmer Raaijmakers. #PKPD #microbiology

Slowly turning orange! Preparing for a series of #hollowfiber experiments of clofazimine containing #antibiotic regimens for #ntmlungdisease. Great work by Sandra Salillas and Jelmer Raaijmakers. #PKPD #microbiology

What this boils down to is using mathematical/statistical models to help explain and predict what the body does to the drug (#Pharmacokinetics, #PK) and what the drug does to the body (#Pharmacodynamics, #PD) - these are often combined to produce #PKPD or #ExposureResponse models.