Blood Vessel Organoids for Development & Disease

Self-organizing capillary blood vessel #Organoid #EndothelialCell+#Pericyte (+Astrocyte for #BBB)

Transplant to gain vascular hierarchy

Organotypism Through Genetic Drivers

Dr. Josef Penninger lab Circ Res 2023
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321768

RT @_TomLongden
Great to see our article on #pericyte control of blood flow in #brain and #heart out in @AnnualReviews. The result of a great collaboration with the Lederer lab here at @UMBaltimore!
https://www.annualreviews.org/doi/full/10.1146/annurev-physiol-031522-034807

Spatial Atlas of human Lung

Spatially-resolved multi-omics-> #AirwaySubmucosalGland-associated Lymphoid niche for IgA #PlasmaCell + T cells via CCL28/IL6/APRIL paracrine

5 locations, 13 patients

Systemic vs Pulmonary vascular trees

Immune recruiting venous NG2-ABCC9+ICAM1+ #Pericyte is abundant in CCL2/19/21 & CXCL12🤠

Love to dig into transcriptomes of systemic vs pulmonary #SmoothMuscleCell & pericytes along the bronchial tree😋

A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

Love this powerful molecular micro-anatomy for human Lung👍

A great starting point for my Holiday-specific continued biomedical education on Lung🎄

Dr. Sarah Teichmann & Kerstin Meyer lab Nature Genetics 2022
https://www.nature.com/articles/s41588-022-01243-4

5-channel (separated by microposts) #Microfluidic for #EndothelialCell-#Pericyte fibrin-
collagen co-culture

Human Lung fibroblast as feeder

Enable study of Synergy b/w #ShearStress & Pericyte on #SproutingAngiogenesis😁

Dr. Ryuji Yokokawa lab, Lab on a chip 2022

Look at this gorgeous movie on Neutrophil (Green) talking with #EndothelialCell (Blue), #Pericyte (Magenta) & #MastCell (Cyan) in Venule during #Diapedesis 2 h post-TNFα challenge 🤩

Perivascular #MastCell IL-17A->
⏫MC-proximal venular #Pericyte/Mural cell (not #EndothelialCell) Surface presentation of ICAM1 & CXCL1->
⏫#Neutrophil #Diapedesis in subendothelial space

Dr. Mathieu-Benoit Voisin lab @NatureComms 2022 @RegisJoulia
https://www.nature.com/articles/s41467-022-34695-7

#Pericyte internalizes-cleaves-degrades α-Synuclein aggregates, even in co-culture with "professional" Microglia😎 (relative efficiency?🧐)

How α-Syn fibril uptake impact pericyte metabolism & functions?
#ParkinsonsDisease

Dr. Birger Victor Dieriks & Mike Dragunow labs @PLOSONE 2022
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0277658

Antigen-presenting #Pericyte #MultipleSclerosis

PDGFRβ+ Pericyte MHCII KO->
In vitro
⏬CD4+ T cell proliferation & activation

In🐭adoptive transfer EAE
⏫CD3+ T cell entry
No change in BBB, CD4+ T cell, Mɸ, cytokine

Dr. Luisa Klotz lab @IJMS_MDPI 2022
https://www.mdpi.com/1422-0067/23/21/13081/htm