Can clofazimine replace rifampicin in Mycobacterium avium complex lung disease treatment? The brilliant Sandra Salillas has modified the hollow fiber model so we can find out! Exciting! #pharmacokinetics #pharmacodynamics #mycobacteria #tuberculosis #NTM #ntmlungdisease @radboudumc

#ESR1 mutations in the docking site of Selective Estrogen Receptor Degraders and Modulators #SERD differentially impact on drug affinity across agents. Integrating #ctDNA and #pharmacodynamics. #PrecisionMedicine #BreastCancer

Visualizing localization of #Lymphocytes during #Immunotherapy in human patients with PET-imaging revealed massive and surprising #Heterogeneity in CD8+ T cell distribution and #Pharmacodynamics within and between patients https://www.nature.com/articles/s41591-022-02084-8

What this boils down to is using mathematical/statistical models to help explain and predict what the body does to the drug (#Pharmacokinetics, #PK) and what the drug does to the body (#Pharmacodynamics, #PD) - these are often combined to produce #PKPD or #ExposureResponse models.

Pharmacometrics rolls up modeling and simulation for #Pharmacokinetics, #Pharmacodynamics, and #DiseaseProgression, with a focus on populations and variability. A major focus is to understand variability in drug response, which can be predictable (e.g. due to differences in body weight or kidney function) or unpredictable (differences between subjects seem random, but likely reflect a lack of knowledge or data).

https://en.wikipedia.org/wiki/Pharmacometrics