"The results show that foldability was likely a critical factor in the selection of the canonical alphabet. Unbranched aliphatic amino acids were purged from the proteinogenic alphabet despite their high prebiotic abundance because they generate polypeptides that are oversolubilized and have low packing efficiency"
https://pubs.acs.org/doi/10.1021/jacs.2c12987#:~:text=The%20results%20show,low%20packing%20efficiency

#biochemistry #originOfLife #RNAworld #ancient #prebiotic