Work continues in this area, but it is showing promise.
#Pregnancy #PretermBirth #Labour #Reproduction
https://knowablemagazine.org/article/health-disease/2023/rna-tests-predict-pregnancy-complications

Cannabis and pregnancy are not compatible.
#pregnancy #cannabis #pretermbirth #ChildHealth
https://www.ctvnews.ca/health/doctors-concerned-more-people-using-cannabis-during-pregnancy-1.6409077

https://www.fda.gov/news-events/press-announcements/fda-commissioner-and-chief-scientist-announce-decision-withdraw-approval-makena #PretermBirth #Rx #FDA

Now available as a free podcast here:
#PretermBirth #Preemies #PretermLabour #Pregnancy #reproduction #NICU #NeonatalCare #MedMastodon

https://pca.st/episode/6c2bf1b5-d460-4679-bb7f-8daa6f51e321

Thank goodness for the #Canadian #healthcare system. Situations like these in other countries such as the #USA could lead to financial ruin.
#PretermBirth #Preemies #PretermLabour #pregnancy #NeonatalIntensiveCare

Story of the world's most premature twins underlines medical, moral challenges of dangerously early births
#PretermBirth #preemies #pregnancy #PretermLabour #reproduction #canada
https://www.theglobeandmail.com/canada/article-most-premature-nadarajah-twins/

Q1 claimed the highest number of trial starts in 2022 — AbbVie knocks down earnings forecast due to IPR&D charge — FDA forces unproven premature birth drug Makena off market -- See more on our front page news http://bit.ly/w28kSd #abbvie #researchanddevelopment #fda #makena #pretermbirth #clinicaltrials #pharma #pharmanews #biotech #biopharma #biotechnology #cafepharma

In the 12 years since Makena was fast-tracked by the FDA, about 350,000 patients received pricey injections to prevent premature birth, a major health issue facing children and families.

There was just one problem: there’s no evidence Makena actually works. My latest for @TheGuardian
https://www.theguardian.com/us-news/2023/mar/23/makena-premature-birth-drug-pulled-us-reaction
#Makena #FDA #PrematureBirth #PretermBirth #MedMastodon

The highest rates of preterm births and infant mortality are in red states that have recently outlawed abortions— the dire statistics are only going to get worse. #MaternalInfantMortality #PretermBirth #AbortionBan #Healthcare

An interesting article on reduced preterm birth rates during the pandemic. Implications stated by authors: “The hypothesis that changes in work-related stress led to reductions in preterm birth during the pandemic is seductive, though the patterns of clinician-initiated preterm birth suggest that obstetric service disruptions may be a simpler and more plausible explanation.”
#PretermBirth #pregnancy #Medicine #ObGyn

https://onlinelibrary.wiley.com/doi/full/10.1111/ppe.12916?campaign=woletoc

Latest from AJOG. “Changing levels of sFlt-1 and PlGF are indicative of placental dysfunction and are strongly associated with the risk of spontaneous preterm birth, especially when combined with slower fetal femur length growth.
#placenta #PreTermBirth #pregnancy #ReproSci #MedMastodon #Science

https://www.ajog.org/article/S0002-9378(23)00077-7/fulltext

Since current therapies are pretty poor at delaying birth and improving neonatal outcomes, this review on the potential for repurposing drugs to inhibit or decrease uterine contractions/inflammation is timely.

#Pregnancy #PretermBirth #PretermLabour #ObGyn #ReproSci #MedMastodon #Labour #Science

https://rep.bioscientifica.com/view/journals/rep/165/1/REP-22-0226.xml

The vaginal microbiome, metabolome, xenobiotics and preterm birth.
#pregnancy #PretermBirth #microbiome #ReproSci #reproduction #Science

“…results demonstrate the potential of vaginal metabolites as early biomarkers of sPTB ‘(spontaneous Preterm birth)’ and highlight exogenous exposures as potential risk factors for prematurity”

https://www.nature.com/articles/s41564-022-01293-8

Key point: “…education level and zip code, both measures of social class, turned out to be the main predictors of risk, both for COVID infection and for pre-term birth during the pandemic.”

#pregnancy #PretermBirth #COVID19 #SocialClass #pandemic

https://www.pnas.org/post/journal-club/covid-19-increases-pregnancy-risks-poorer-communities-shouldering-most-burden

AJOG article out in January 2023:

Key point: “provided proof of principle of how noninvasive methods suitable for point-of-care systems can select high-risk cases among women with preterm labor and might substantially aid in clinical management and outcomes while improving the use of resources and patient experience”

#PretermBirth #pregnancy #AmnioticInfection #MedMastodon #ObGyn #Reproverse #ReproSci

https://www.ajog.org/article/S0002-9378(22)00581-6/fulltext

Living in an area with high police presence increases the odds of a premature birth for both Black and white residents. Greater police presence in Black vs white neighborhoods may contribute to the persistent Black-White preterm birth disparity.

https://www.ncbi.nlm.nih.gov/pubmed/34878551

#NICHDimpact #Prematurity #PrematureBirth #Race #RacialDisparity #PretermBirth #Neighborhoods #PolicePresence #NeighborhoodPolicing

Researchers found exposure to #Prozac provoked inflammatory response in the amniotic sac.
Yale School of Medicine's Vikki Abrahams, PhD, says the effect offers a possible explanation for higher risk of #pretermbirth in mothers on #SRI antidepressants during #pregnancy.

https://news.yale.edu/2022/12/15/inflammation-may-explain-antidepressants-link-preterm-birth

New AJOG Preprint.

Key Finding: “SARS-CoV-2 infection within the first two trimesters of pregnancy was associated with an increased risk of early preterm birth (PTB) (≤32 weeks) and stillbirth compared to infection within the third trimester. The risk of PTB was higher within the first 4 weeks after infection.”

#COVID19 #MedMastodon #pregnancy #PretermBirth #stillbirth

The url:
https://doi.org/10.1016/j.ajog.2022.11.1301

Proinflammatory changes in the maternal circulation, maternal–fetal interface, and placental transcriptome in preterm birth - ScienceDirect.
#Reproverse #ReproSci #PretermBirth

https://www.sciencedirect.com/science/article/pii/S0002937822006779

The main point: “High Breast Milk (sic) exposure following preterm birth is associated with a cortical imaging phenotype that more closely resembles the brain morphology of term-born infants and effects appear to be dose-dependent.”
#PretermBirth #Neurology #ScienceMastodon

Breast milk exposure is associated with cortical maturation in preterm infants - Sullivan - Annals of Neurology - Wiley Online Library

https://onlinelibrary.wiley.com/doi/10.1002/ana.26559