Does anyone have any experience with running #alphafold #openfold on ARM-based GPU? I’m interested to know if current DL code is moving in this direction… (secretly/desperately) hoping so. Any insight would be appreciated especially on new DL for docking, engineering etc #proteinstructure #structuralbiology

New Title Alert: RFdiffusion is new to the #SBGrid software collection. This is an open source method for structure generation, with or without conditional information (a motif, target etc). It's a powerful new way to design proteins by combining structure prediction networks and generative diffusion models.

https://www.bakerlab.org/2023/07/11/diffusion-model-for-protein-design/

Read more at
De novo design of protein structure and function with RFdiffusion

https://www.nature.com/articles/s41586-023-06415-8

#structuralbiology #Science #research #proteinstructure

RT @grnfluoresceblg
Wow, from the abstract this paper from @Mayr_Christine lab looks super interesting!

"mRNA interactions with disordered regions control protein activity"
#mRNA #translation #mRNALocalization  #ProteinStructure #RNAbinding

https://www.biorxiv.org/content/10.1101/2023.02.18.529068v1

Wow, from the abstract this paper from Christin Mayr lab looks super interesting!

"mRNA interactions with disordered regions control protein activity"
#mRNA #translation #mRNALocalization #ProteinStructure #RNAbinding

https://www.biorxiv.org/content/10.1101/2023.02.18.529068v1?med=mas

Raman spectroscopy shows simultaneous, label-free imaging of RNA, DNA, and proteins, revealing secondary structural features of intracellular LLPS organelles, and condensed chromosomes. 🧬🔍

https://doi.org/10.1038/s42003-022-04342-4
#RNA #DNA #ramaneffect #proteinstructure #openaccess

Referenced link: https://phys.org/news/2022-11-3d-protein-ai-boost-cancer.html
Discuss on https://discu.eu/q/https://phys.org/news/2022-11-3d-protein-ai-boost-cancer.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/physorg_com/status/1590013589124878336#m

3D ##proteinstructure predictions made by AI could boost cancer research and drug discovery @IJCResearch @NatureSMB https://www.nature.com/articles/s41594-022-00849-w https://phys.org/news/2022-11-3d-protein-ai-boost-cancer.html

Your reminder that protein crystals are beautiful and wonderful.

#Crystallography #ProteinStructure #Science