Good news bad news: it sounds like eventually there will be more paleo-proteomics hitting the news cycle (à la tears of blood).

“[they] have used this method to explore a range of archives, arousing both excitement and consternation among historians, as the researchers report the unsuspected activities of iconic figures from Johannes Kepler to Joseph Stalin.”

https://www.smithsonianmag.com/history/document-detectives-use-smudges-bloodstains-investigate-past-180980986/

#proteomics #vlad

First speaker of the session (Cell identity in situ)
is Elana Fertig
of Convergence Institute at Johns Hopkins
https://fertiglab.com/

She has background in weather prediction (!) ⛈️ which has convergence with predictive medicine (such as huge data sets)

Looks at #PancreaticCancer with spatial #proteomics
now #scRNAseq

Developed CoGAPS matrix factorization, can identify cell state transitions

Using PhysiCell to build models
http://physicell.org/

#cancer
#SingleCell
#CSSingleCells23

1/2

Happy to announce that we've just put up our preprint for the #OpenMS 3.0 release:

https://www.researchsquare.com/article/rs-3286368/v1

OpenMS is the by far the largest software project that I've ever worked on, and this is the first major release during my tenure here. Happy to answer any questions.

#TeamMassSpec #FOSS #OpenScience #OpenSource #Proteomics #massSpectrometry

I am listening to this great lecture by Michelle Heck, and it made me think about some other great lectures I've missed (I still have a list from lockdown). One big one I haven't tracked down is the Jimmy Eng talk at HUPO 2020 (I think @pwilmart recommended it at the time). But... I have no idea where this video is! Any help from the masses, and sorry to be lazy.

#Proteomics #teamproteome

I just went through a submission with MDPI Genes of an update to a preprint I wrote in 2018 and never "published", and it didn't feel predatory or subpar. The reviewers comments were spot on and aligned with the previous comments from 2018 from two "prestigious journals" who asked for revisions that were beyond me in 2018. This time I *was* able to address these concerns. Point being, broad strokes I am sure MDPI is predatory, but my experience was good and my paper is solid.
#Proteomics #DORA

@pastelbio I guess the HP D100 would fall under FACS, right? Seems like a no brainer for me, but I am definitely partial to cheap things with consumables (side-eye looking at you MS).

(HT @proteomicsnews)

(and is the D300e literally an old ink jet from the 2000s?!)

#SingleCell #Proteomics

Check me please #teamProteome: “quant” at the protein level seems normally distributed across most sample types (high and low abundance tails), but adding depth (new MS) doesn’t preserve the low abundance tail.

Is the drop off tail biologically “real”?

Ex. blood/secretome from Anderson^2 to Uhlén.

#Proteomics

Put in an application to join the US HUPO Advisory Board, due Aug 15. #Proteomics

https://www.ushupo.org/advisoryboard

We are 6 episodes into the second season of #TheProteomicsShow and continue to have great guests. Check it out wherever you get podcast. #Proteomics

Did Count Dracula cry tears of blood? Proteomics for the answer! (h/t @pastelbio)

I feel like this paper may be a stretch (the authors do a great job of qualifying their results), but I love the curiosity and the process. #Proteomics

https://pubs.acs.org/doi/full/10.1021/acs.analchem.3c01461

#TeamMassSpec #Proteomics #MassSpectrometry: Have you used or hear of #OpenMS? Would you be interested in filling out a survey to guide our future development? Please go to: https://www.surveymonkey.de/r/9F6TMJL
You will get my gratitude, and, for a limited time, if you toot me that you filled it out a free random fact of my choosing. Come help support #OpenScience #FOSS #OpenSource

@ClaireEEyers @pastelbio

I mean, the references people use are a constant mystery, especially in this case. I think that 2008 paper may be the first too?

Super cool you use it for QC in HTP. Is it clean or as a spike?

#Proteomics

I’m the late 00’s I was enamored with AFFF-MALS (or DLS), and am always surprised I am not hearing about folks using it upstream of proteomics. Could definitely work (and did for me in 2008) for EVs and likely work for some organelles and even some cell types (I don’t actually know the upper limit on size range).

Is it something Wyatt did or…?

#proteomics #teamproteome #teammassspec

This study strengthens caution of quickly extrapolating animal model studies to humans, and vice versa.
“…the assessment of human–animal relationships is important for translational studies. We believe that our data will also help to identify which species should be used in specific settings or as an animal model.” #physiology #animalmodels #Proteomics #biology #translationalscience

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338492/

Referenced link: https://medicalxpress.com/news/2023-06-angle-alzheimer-csf-proteomics-metabolic.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-angle-alzheimer-csf-proteomics-metabolic.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1666436960192217089#m

RT by @physorg_com: Another angle on Alzheimer's: CSF, #proteomics, and metabolic enzymes @bostonchildrens @CellRepMed https://linkinghub.elsevier.com/retrieve/pii/S2666379123001155 https://medicalxpress.com/news/2023-06-angle-alzheimer-csf-proteomics-metabolic.html

#ASMS2023 here we go! Looking forward to a week of science, (re)connecting with #TeamMassSpec folks and talking phospho-#proteomics. Hit me up if you're in Houston, Texas

@RonBeavis
See also
"The sine qua non condition for the dataset is the possibility to run MaxQuant on it"

The two statements kinda fit together though I suppose.

#teammasspec #Proteomics

RT @APSPublications
New in @ajpheartcirc! Multiomics uncover the proinflammatory role of Trpm4 deletion after #myocardial infarction in mice 🐭(Boukenna et al.)

http://ow.ly/slJ450NpmC0

@SwissIonChannel #CardiacInflammation #proteomics #transcriptomics

RT @PIXIELabKCL@twitter.com

We are only a week away from our next #immunopsychiatry meeting! 🤩@Strawbr1@twitter.com will talk about #inflammatory markers in #TRD treatment and Dr. Melanie Focking - #proteomics and #psychosis (link on the day). Look forward to seeing you on Monday!

🐦🔗: https://twitter.com/PIXIELabKCL/status/1614994881302401025

RT @MirkoSinger
Especially happy to shed some light on #invasion of #apicomplexa by integration of #proteomics data, thanks to Dr. Ignasi Forné, with structure prediction using #Colabfold and colocalization analysis using 3D-STED. @PLOSBiology #plosbiologyauthor https://twitter.com/MeissnerLab/status/1611075593684017155