@linseigh I’m a little late, but I was just scrolling through the #spoonie posts to feel less alone and offer some support. My #RareDisease is #PulmonaryArterialHypertension. Twelve in a million of us have it. It’s awful! Hang in there, fellow #spoonie 🌻

I did my lung exercises AND my stupid boring leg exercises for the first time since I got out of the hospital.

I have a hard time walking from the bedroom to the kitchen. Scary. If I remember right, I was this bad before I started physical therapy but improved quickly. Fingers crossed that happens again. I don’t want to go to a nursing home yet.

#ChronicIllness #PulmonaryHypertension #PAH #PulmonaryArterialHypertension

Epigenetics #PulmonaryArterialHypertension

JMJD1C a histone demethylase
⏫p-STAT3->
⏫#Glycolysis HK2/PGK1/LDHA->
⏫PA #SmoothMuscleCell Proliferation

Serum Lactate⏬by AAV2-shJMJD1C in🐭#Hypoxia-PAH
Local effect on #EndMT?

Dr H Zhao lab Cell Death Discovery 2023
https://www.nature.com/articles/s41420-023-01390-5

No. Pump. Alarms. Last. Night.

I don’t know why I need to put in a 100% charged battery every night before bed (these batteries are supposed to be good for 72+ hours) but that’s the solution. And it’s easy!

It has been a full week, so I’m calling it SOLVED! And the problem is not me! Happy dance!

#Remunity #PulmonaryHypertension #PulmonaryArterialHypertension #Remodulin #PAH

Tie2+ #EndothelialCell Egln1/PHD2 KO mice
->Spontaneous #PulmonaryArterialHypertension as early as 1.5 mo

A cascade of EC PHD2 KO->
⏫autocrine #CXCL12->
⏫FoxM1-dependent proliferation

Dr. Zhiyu Dai lab IJMS_MDPI 2021
https://www.mdpi.com/1422-0067/22/6/3182

Also read Dr. Dai Circulation 2016🤠presenting EC PHD2 KO, causing PAH via HIF2α (not HIF1α)

PHD2 Deficiency in Endothelial Cells & Hematopoietic Cells Induces Obliterative Vascular Remodeling & Severe Pulmonary Arterial Hypertension PAH in🐭👤Through HIF2α
https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.116.021494

#CardioMedMastodon Cardiopulmonary Pathogenic Networks: Unveiling the Gut-Lung Microbiome Axis in #PulmonaryArterialHypertension @NIH
https://www.atsjournals.org/doi/pdf/10.1164/rccm.202211-2126ED?download=true

Just published this review on #PulmonaryArterialHypertension clinical trials in the Lancet.

We discuss progress to date, current challenges, and need for innovations in trial design and outcome definitions.
#PAH #RCTs

Link to free article for the next 50 days
👇
https://authors.elsevier.com/a/1g8Y1V-4XHG0E

Here is the 4th and final post in my short thread. I have #PAH #PulmonaryArterialHypertension which is a rare, horrible, degenerative, incurable disease. The treatments are almost as bad as the disease itself. Anyone else out there? Probably not — there are only a few hundred thousand of us worldwide.