Sugammadex showed no benefit over neostigmine when assessed using PACU spirometry, muscle strength, TOFR or other indicators of recovery up to 2 hours post-reversal.
- Abola 2020 CanJAnaesth #RCT
→ metajournal.com/32405975

A small QTc prolongation seen with carbetocin is unlikely to be clinically significant.
- Clunies-Ross 2021 Anesth.Analg. #RCT
→ metajournal.com/32149759

Hello sciences.social! I work on social policy and programme evaluations, primarily RCTs and quasi-experiments, at the National Centre for Social Research (NatCen) in London, UK.

#introduction #evaluation #ProgramEvaluation #PolicyEvaluation #SocialScience #ProgrammeEvaluation #CausalInference #RStats #DAGs #methodology #RCT #QuasiExperiment

Intrapartum fetal ECG monitoring and ST-segment analysis does not lead to better fetal or delivery outcomes compared with standard FHR and CTG monitoring.
- Belfort 2015 N.Engl.J.Med. #RCT
→ metajournal.com/26267623

Learning in a simulated anesthesia crisis is better when the simulation is of independent practice than supervised practice.
- Goldberg 2015 BrJAnaesth #RCT
→ metajournal.com/25571933

In patients with atrial fibrillation requiring cessation of warfarin for surgery, bridging anticoagulation does not change the incidence of thromboembolism, although does increase major bleeding.
- Douketis 2015 N.Engl.J.Med. #RCT
→ metajournal.com/26095867

"Yeah, it works great in a healthy 60-year-old, but how does it work in the general population? ... The population that we’re intending to use the vaccine in, how well does it work? What can we anticipate? What’s the cost-effectiveness of the vaccine?"

Vaccine experts urge more inclusivity in clinical trials

https://www.statnews.com/2023/09/05/vaccine-experts-urge-more-inclusivity-in-clinical-trials/

#Vaccine #RSV #ClinicalTrial #RCT #IDMastodon #InfectiousDiseases

Neuraxial analgesia early in labor does not increase the risk of cesarean delivery or increase the duration of labor compared with analgesia later in labor.
- Wong 2005 N.Engl.J.Med. #RCT
→ metajournal.com/15716559

In patients having laparoscopic abdominal surgery, there was no difference in incidence of delayed neurocognitive recovery between propofol and sevoflurane-based anaesthesia.
- Li 2021 Anesthesiology #RCT
→ metajournal.com/33439974

Sevoflurane-based anesthesia is associated with a similar incidence of myocardial ischema as for propofol-based anesthesia.
- Buse 2012 Circulation #RCT
→ metajournal.com/23136158

Intraoperative PEEP and recruitment manoeuvres reduce ultrasound-detected atelectasis intraoperatively but showed no post-extubation benefit after open gynaecological surgery.
- Généreux 2020 BrJAnaesth #RCT
→ (summary) metajournal.com/31733807

Brain tissue oxygentation monitoring after severe traumatic brain injury may improve mortality and neurological morbidity compared with ICP monitoring alone.
- Okonkwo 2017 Crit.CareMed. #RCT
→ metajournal.com/29028696

Neither perioperative aspirin or clonidine show long-term benefit in terms of death, cardiovascular complication, cancer, or chronic pain at 1 year, except for a benefit of aspirin for patients with a history of PCI.
- Sessler 2020 Anesthesiology #RCT
→ metajournal.com/32022771

I'm pretty sure this little bit of absurdity hasn't gotten enough press coverage https://riskybiznews.substack.com/p/risky-biz-news-canadas-tax-revenue

@CBCNews@press.coop @thetyee

#Canada #RCT

BIS monitoring significantly reduces the risk of awareness under general anesthesia in high-risk adult surgical patients.
- Myles 2004 Lancet #RCT
→ metajournal.com/15172773

Optimal intraoperative PEEP varies among patients. Individualizing PEEP reduces post-operative atelectasis.
- Pereira 2018 Anesthesiology #RCT
→ metajournal.com/30260897

Prophylactic intraoperative IV pentazocine reduces the incidence and severity of post-operative pruritis due to intrathecal morphine used for elective Caesarean section.
- Hirabayashi 2017 Anesth.Analg. #RCT
→ metajournal.com/28448397

Prophylactic intrathecal morphine does not reduce the incidence or severity of post-dural puncture headache.
- Peralta 2020 Anesthesiology #RCT
→ metajournal.com/32108686

Pretty exciting to see oral amphotericin behaving comparably to IV amphotericin for #HIV associated #Cryptococcus #meningitis

Phase 2 open label #RCT, so not quite there yet, but big potential win in simplicity and access to treatment for
#Cryptococcusneoformans & other #fungal diseases, potentially even #mucor

#infectiousdiseases #mycology #IDMastodon #MedMastodon #medicine @infectiousdiseases

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad440/7246927

@noodle @infectiousdiseases @microbiology we definitely use it alongside or often after trying methenamine. However, evidence for its efficacy remains scant. This is the best evidence from an open-label #RCT https://link.springer.com/article/10.1007/s00345-013-1091-6
#recurrent #UTI #IDMastodon #infectiousdiseases #medicine #MedMastodon