Referenced link: https://medicalxpress.com/news/2023-03-blood-stem-cells-rna-splicing.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-blood-stem-cells-rna-splicing.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1638204839007080452#m

RT by @physorg_com: What makes blood stem cells transform? Regulation of #RNAsplicing may be an answer @MolecularCell https://linkinghub.elsevier.com/retrieve/pii/S109727652300151X https://medicalxpress.com/news/2023-03-blood-stem-cells-rna-splicing.html

'Gene duplication and diversification allow hosts to mutate otherwise essential genes, whereas changes in transcriptional regulation can selectively activate genes should their constitutive expression be detrimental. To counter mutational tolerance, it has been suggested that viruses target essential genes as host cofactors, because the genes are less prone to variability'

#Virology #HostPathogen #RNASplicing

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001934

"Here, we utilized unbiased genetic screens to map drug/gene interactions for a variety of clinically approved therapies used in the treatment of AML. This effort highlighted a unique genetic relationship between response to venetoclax and the function of specific RNA splicing factors."

#AML #leukemia #venetoclax #BCL2 #Apoptosis #RNASplicing #AcuteMyeloidLeukemia

https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00588-8

Referenced link: https://medicalxpress.com/news/2022-10-rna-splicing-defects-contribute-alzheimer.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2022-10-rna-splicing-defects-contribute-alzheimer.html

Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/medical_xpress/status/1580660664250400768#m

RT by @physorg_com: Model demonstrates how #RNAsplicing defects contribute to Alzheimer's disease @NatureAging https://www.nature.com/articles/s43587-022-00290-0 https://medicalxpress.com/news/2022-10-rna-splicing-defects-contribute-alzheimer.html