"However, binding and neutralization have poorly predicted protection in the past, and accumulating data across epidemiologic cohorts and animal models collectively point to a role for additional antibody Fc-effector functions. To begin to define the humoral correlates of immunity against RSV, here we profiled an adenovirus 26 RSV-preF vaccine-induced humoral immune response in a group of healthy adults that were ultimately challenged with RSV."

#Immunology #RespiratorySyncytialVirus #virus #Antibody

https://www.cell.com/cell/fulltext/S0092-8674(22)01424-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422014246%3Fshowall%3Dtrue

"Older vaccines use the postfusion, or Post-F, version of the protein, whereas new vaccines employ a prefusion stabilized, or Pre-F, immunogen. Here, Chang and Phung et al. directly compared immune responses elicited by a Post-F vaccine, MEDI7510, and a Pre-F vaccine, DS-Cav1. The authors found that DS-Cav1 elicited antibodies that more potently neutralized RSV A and B than MEDI7510. This enhanced response was mediated by the presence of antibodies that could bind sites on the F protein that were only present in the Pre-F state."

#RSV #RespiratorySyncytialVirus #Immunology #Vaccine

https://www.science.org/doi/abs/10.1126/scitranslmed.ade0424

Which Virus Is It This Time? New Yorkers Are Sick of Being Sick. https://www.nytimes.com/2022/12/16/nyregion/covid-flu-rsv-sick.html #RespiratorySyncytialVirus(RSV) #Coronavirus(2019-nCoV) #ChildrenandChildhood #StrepThroat #NewYorkCity #Influenza #Viruses

RSV FAQ: What is RSV? Who is at risk? When should I seek emergency care for my child?
#Health #RSV #RespiratorySyncytialVirus #Children #EmergencyCare
https://the-14.com/rsv-faq-what-is-rsv-who-is-at-risk-when-should-i-seek-emergency-care-for-my-child/