"Runx co-factors compete to recruit a limited pool of Runx factors in early T-progenitors, and a modest increase in Runx protein availability at pre-commitment stages causes premature Runx occupancy at post-commitment binding sites. This results in striking T-lineage developmental acceleration by selectively activating T-identity and innate lymphoid cell programs."

#Immunology #Preprint #Runx #thymus

https://www.biorxiv.org/content/10.1101/2022.11.18.517146v1?med=mas