SenMayo
A 125-gene set (15 studies) for #Senescence/#SASP in Bone/Bone marrow/Adipose/Brain...

#Senolytic readout

vs GenAge & CellAge

MIF as a key SASP gene!

Dr. Dominik Saul, Joshua Farr & Sundeep Khosla labs Nature Comms 2022
https://www.nature.com/articles/s41467-022-32552-1

#Senescence #ImmuneSurveillance
Next-gen #Senolytic

#ImmuneCheckpointBlockade activates CD8+ T cytotoxicity against (inflammed🔥) PD-L1+ senescent cells->
⏬adverse phenotypes in🐭#Aging+#NASH

Dr. Yoshikazu Johmura & Makoto Nakanishi labs Nature 2022
https://www.nature.com/articles/s41586-022-05388-4