"Using zebrafish, we identified Down syndrome cell adhesion molecule like-1 (dscaml1) as an integral mediator of CRH neuron development and necessary for establishing normal stress axis function...these findings identify dscaml1 as an essential factor for stress axis development and suggest that HPA axis dysregulation may contribute to the etiology of human DSCAML1-linked neuropsychiatric disorders"
https://www.frontiersin.org/articles/10.3389/fcell.2023.1113675/full#:~:text=Using%20zebrafish%2C%20we,linked%20neuropsychiatric%20disorders

#developmentalBiology #hpaAxisDysfunction #Stresshormone