Treg cells are a category of T cells whose properties make them a candidate for potential treatment therapies for #IBD. We eagerly await the outcome of clinical trials using this approach that are currently underway.

#crohns #crohnscolitis #crohnsandcolitis #inflammatoryboweldisease #treg #tcells #tcell

Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states | Science Translational Medicine https://www.science.org/doi/10.1126/scitranslmed.adg9452 “#Omicron-reactive #Tcell responses that increased markedly upon #booster #vaccination and correlated directly with #antibody #titers across all patient groups. Poor vaccination responsiveness in #immunocompromised or #elderly individuals was effectively counteracted by the administration of additional doses.”

Neutralizing activity & #TCell response after bivalent fifth dose of mRNA vaccine in person living with #HIV
📌 https://www.sciencedirect.com/science/article/pii/S120197122300632X?dgcid=raven_sd_aip_email
📌 https://www.sciencedirect.com/journal/international-journal-of-infectious-diseases

#IDMastodon @ISID_org An unusual presentation of invasive Fusarium #aortitis in an immunocompromised patient Recentl ,invasive disseminated fusariosis Cases have been increasingly reported in hematological patients with #neutropenia & #Tcell #immunodeficiency . Despite the recent advances in #antifungal development, the disease has a poor prognosis with high mortality, given the limited treatment options due to frequent multiple intrinsic resistances.

https://www.cell.com/cell/fulltext/S0092-8674(23)00403-8 “#BNT162b4 encodes variant-conserved, immunogenic segments of the #SARSCoV2 #nucleocapsid, membrane, and ORF1ab proteins, targeting diverse #HLA alleles. BNT162b4 elicits polyfunctional #CD4+ and #CD8+ #Tcell responses from diverse #epitopes in animal models, alone or when co-administered with BNT162b2 while preserving spike-specific immunity. Importantly, we demonstrate that BNT162b4 protects hamsters from severe disease and reduces viral titers”

#Immunoly #IDMastodon @Nature
The dietary sweetener sucralose is a negative modulator of #Tcell-mediated responses & impairs T cell proliferation and differentiation
📌 https://www.nature.com/articles/s41577-023-00873-x.pdf
📌 https://www.nature.com/articles/s41586-023-05801-6.pdf

An interesting new double act!!

#Tcell immunotherapies engage #neutrophils to eliminate tumor antigen escape variants

https://doi.org/10.1016/j.cell.2023.03.007

#MTOR plays a crucial role in #TCell responses during chronic viral infection & Accelerated T-cell exhaustion: its pathogenesis and potentially severe outcomes in #COVID19
📌https://link.springer.com/article/10.1007/s13577-022-00814-1
📌 https://www.jci.org/articles/view/160025

#IDMastodon #molecular #biochemistry 1st pathogen can cause an accelerated #TCell exhaustion for a second pathogen cellular infection. Accelerated T-cell exhaustion for 2nd pathogen weakens T-cell targeting of 2nd pathogen & enables 1st time infection by the second pathogen to replicate quickly and extensively. T-cell exhaustion has been repeatedly linked to #COVID19 cases with severe outcomes and/or mortality
https://link.springer.com/article/10.1007/s11010-023-04680-9

HPV Vaccine Generates Immune Responses in Trial

Early results from a clinical trial show a #vaccine for the human #papillomavirus is safe and invokes #immune responses in women with low-grade #cervical #lesions.

https://sciencebusiness.technewslit.com/?p=44592

#News #Science #Business #HPV #HumanPapillomavirus #Cancer #Immunotherapy #Cervix #ClinicalTrial #TCell #SyntheticBiology #OxfordUK

#IDMastodon @ImmunityCP
Robust #TCell responses to Pfizer/BioNTech vaccine compared to
infection and evidence of attenuated peripheral CD8+ T cell responses
due to #COVID19
📌 https://www.cell.com/immunity/pdf/S1074-7613(23)00125-5.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761323001255%3Fshowall%3Dtrue
📌 https://www.cell.com/immunity/fulltext/S1074-7613(23)00125-5?rss=yes&utm_source=dlvr.it&utm_medium=twitter

“T cells are immune cells produced by the thymus gland; they are released from the thymus gland & enter the bloodstream, ready to wipe out any foreign invaders in the body, being a major killer of cancer cells.

— Dr. Kevin Conners

T-cells are so important for those struggling with cancer or other autoimmune diseases. These are the cells that are responsible for killing the bad cells! However, many western therapies, such as chemotherapy & radiation, severely compromise a person’s immune system, which is an issue for T-cell production.

Stimulating the thymus gland can help regulate T-cell production & immune activity. Different products, such as Cytozyme-THY, can support the thymus gland.

Learn more about T-cells by going to ConnersClinic.com/Blog OR click on the link in our bio for more!

#connersclinic #devotionals #bibletalk #biblememe #tcell

#Onclogyresearch @Nature #antigenspecific CD8+ #TCell accumulation in #tumors is a prerequisite for effective #Immunotherapy & the mechanisms of lymphocyte transit
https://www.nature.com/articles/s41590-023-01443-y.pdf

Cancer Immunology Scientist/Sr Scientist – TIL Therapy @RetroBio_

https://buff.ly/3xxgbec

#ScienceJobs #Tcell

Aspiring to add 10 years to healthy human lifespan, starting with cellular reprogramming, autophagy, & plasma-inspired therapeutics.

@RetroBio_ has multiple #ScienceJobs open 🧵

Redwood City, US #biotech #Startup #Tcell

Researchers from Karolinska Institutet have discovered that the #genes encoding our T #cell receptors vary greatly between persons and populations, which may explain why we respond differently to, for example, #infections. The findings also demonstrate that some gene #variants are inherited from #Neanderthals.
#Biology #sflorg #Tcell
https://www.sflorg.com/2023/02/bio02152302.html

#oncologresearch @kochinstitute A new study from the Spranger Lab pinpoints a reason why lung cancer doesn’t respond well to #immunotherapy: lymph nodes near the lungs create an environment that weakens #Tcell responses to tumors.
https://news.mit.edu/2023/lung-cancer-t-cells-doesnt-respond-well-immunotherapy-0202

#LongCOVID
manifests with #Tcell dysregulation, inflammation, and an uncoordinated adaptive
immune response to #SARSCoV2

"Our findings demonstrate that
individuals with LC exhibit systemic inflammation and immune dysregulation."

https://www.biorxiv.org/content/10.1101/2023.02.09.527892v1

#COVID19 #SARS2

“Spacing the first two doses of #SARSCoV2 #mRNA #vaccines beyond 3–4 weeks raised initial concerns about vaccine efficacy. ..studies have since shown that long-interval regimens induce robust antibody responses, .. we compare SARS-CoV-2 naive donors #Bcell and #Tcell responses to two mRNA vaccine doses administered 3–4 versus 16 weeks apart. After boost, the longer interval results in a higher magnitude and a more mature phenotype of RBD-specific B cells.”

https://www.cell.com/iscience/fulltext/S2589-0042(22)02177-0?rss=yes&utm_source=dlvr.it&utm_medium=twitter

#IDMastodon #Immunology #Clinicalreports #Clinicalstudy @jacionline. #Lymphopenia, particularly restricted to #Tcell compartment, has been described as one of the major clinical hallmarks in COVID-19 patients and proposed as a disease severity indicator. @Velardi_Lab et al demonstrate that the human thymus is a target of #SARSCoV2 & that thymic function is impaired in #COVID19 patients.
https://www.jacionline.org/article/S0091-6749(23)00147-1/pdf