#LongCOVID as a #Tauopathy Of “Brain Fog” and “Fusogen Storms”
https://www.mdpi.com/1422-0067/24/16/12648

Good stuff from the Steen lab! @ionicwoman
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RT @ionicwoman
Kathrin Wenger and our team asked, Why do drugs for Alzheimer’s Disease work in animal models, but often fail in clinical trials?
https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00601-y
#AlzheimersDisease #tauopathy #proteomics #HarvardMed #neurodegeneration #dementia
https://twitter.com/ionicwoman/status/1621281689896103936

This is what #EPAD and other studies are showing. #APOE4 is such a huge risk factor for #Alzheimer's (akin to a decade of ageing) that it's basically a different, #amyloid-heavy disease. There are other routes to #Tauopathy in those with e.g. E3/E3. Paper from the great and good here https://www.nature.com/articles/s41583-021-00533-w
But if Amyloid++ 4/4 genotypes predict best response AND worse SE to anti-Amyloid therapies, shouldn't we start to TEST for it and learn how best to communicate results?