How does the #metabolism impact regulatory #Tcell #Immunobiology ? Elegant talk by Guoliang Cui at #cimt2023 in Mainz #HI-TRON #immunology

RT @cellhostmicrobe
Fuso induces tumor resistance to #immunotherapy. New work reports that Fusobacterium nucleatum-derived succinic acid diminishes sensitivity to anti-PD-1 mAb in #ColorectalCancer by impairing CD8+ #Tcell-mediated antitumor immunity https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00161-0

Congrats to @eelisamarchiori, who was awarded a #PhD Fellowship from the @Boehringer Ingelheim Fonds for her ambitious research! 🎉Elisa is a student in the lab of Joris van der Veeken, where she investigates #Tcell differentiation. 👇🏽
https://www.imp.ac.at/news/article/boehringer-ingelheim-fonds-to-support-t-cell-research

DNA sensing via the #cGAS/STING pathway regulates #immunoproteasome function and #MHC class I #antigen presentation to promote #Tcell activation - with implications for the pathology of idiopathic pulmonary fibrosis

Silke Meiners et al ForschungszentrumBorstel@norden.social

https://www.embopress.org/doi/10.15252/embj.2022110597

Remembering #DonMason, a #giant in the #Tcell field #crossreactivity #specificity #TCR @NatImmunol @UniofOxford https://www.nature.com/articles/s41590-021-00884-7

An Immunological Review of SARS-CoV-2 Infection and Vaccine Serology: Innate and Adaptive Responses to mRNA, Adenovirus, Inactivated and Protein Subunit Vaccines
#COVID19 #vaccines #Pfizer #BioNTech #Oxford #AstraZeneca #Sinopharm #Novavax #antibody_response #Tcell #Bcell #neutralizing_antibodies #adaptive #immune #response #immunology
https://www.mdpi.com/2076-393X/11/1/51

@BioMed_X is thrilled to announce the launch of its new immunology discovery platform, which will allow for the accurate & fast identification of target antigens of human T cell receptors.

The underlying technology emerged from a collaboration between the BioMed X Institute and Janssen Inc. The team of researchers who developed this technology in Heidelberg, Germany, was led by Dr. John M. Lindner.

Read more about it in our press release: https://bio.mx/news/press-releases/biomed-x-launches-new-t-cell-immunology-discovery-platform-009982/

#TCell #immunology

#innateimmunity alone is able to induce #tumor regression in an experimental #model of #glioblastoma : intravenous TLR7/8-agonist-loaded #nanoparticles lead to #Tcell -independent eradication of tumor cells. #macrophages #immunology // orchestrated tumor clearing through pro-inflammatory activation of tumor-associated myeloid cells, independent of T cells and #NKcells .
https://www.nature.com/articles/s41467-023-36321-6

more #immunology opinions by Brian Laidlaw on #Bcell memory
https://www.sciencedirect.com/science/article/abs/pii/S0952791522001285

#Bcell - #Tcell collaboration in the lung, @wadschma & @dpschreiner @unibasel
https://www.sciencedirect.com/science/article/pii/S0952791523000031

#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473

So happy for the talented @MarcelTrefny formally in Zippelius lab @unibasel; read about their exciting findings ona new target for #Tcell exhaustion here: rdcu.be/c4HIx

RT @maini_lab@twitter.com

🚨OUT NOW🚨 @Nature@twitter.com
We show myeloid cells instruct CD8+ #Tcell function in the human #liver
Study led by the BRILLIANT @ljpally@twitter.com (now @pallett_lab@twitter.com) working with AMAZING team in @maini_lab@twitter.com, other @SLMS_UCL@twitter.com labs & external collaborators

https://www.nature.com/articles/s41586-022-05645-6

🧵⬇️🤩

🐦🔗: https://twitter.com/maini_lab/status/1618284591936344065

My first post on Mastodon after a whole lot of lurking and boosting, so I'm treating this as a mini #introduction for myself

I'm an #immunology PhD candidate at #ColumbiaUniversity medical center, and we just published a study of #TissueSpecifity of human #Tcell identity and clonal expansion in barrier sites, using #CyTOF, #scRNAseq, and #TCR #sequencing!

https://www.nature.com/articles/s41590-022-01395-9

@gpollara now it's on my short list (hopefully this week!) sounds like chicken or the egg for the #Tcell repertoire in terms of which one to target

RT @ScienceMagazine@twitter.com

#Tcell immunity may be critical for long-term protection by #COVID19 vaccines, according to a #SciencePerspective from last year that highlighted the potential importance of T cell responses in achieving robust protection against severe disease. https://scim.ag/1aC

🐦🔗: https://twitter.com/ScienceMagazine/status/1614653715431964672

Thanks to great work from
Pam Rosato, Hanna Degefu and Tyler Searles, we've updated our #biorxiv preprint led by Kristin Fitzpatrick describing the development and use of an easy and robust bead-based approach to validate and monitor ligand tetramer performance for detection of antigen-specific lymphocytes by #flowcytometry. #antigenspecific #Tcell #Bcell https://www.biorxiv.org/content/10.1101/2022.10.24.513230v2

With the #new #funding anticipated, our lab is seeking #postdocs #bioinfomatician please reach out. #TCRs #autoimmunity #Tcell and #protein #engineering background preferred http://saligramalab.org/

With the #new #funding anticipated, our lab is seeking #postdocs #bioinfomatician please reach out. #TCRs #autoimmunity #Tcell and #protein #engineering background preferred http://saligramalab.org/

Mechanical forces impair #antigen discrimination by reducing differences in #Tcell receptor/peptide–#MHC off-rates

New article by Johannes Pettmann, Lama Awada et al

https://www.embopress.org/doi/10.15252/embj.2022111841

My latest #compchem paper published in #ScientificReports
nature.com/articles/s41598-022-25603-6

#moleculardynamics #simulation of Src family Tyr #kinase Lck in a #Tcell #membrane environment: Full-length #protein dynamics, #lipid interactions, conformational change.

Study highlights: twitter.com/DJ_Biophys/status/1525101069332021248