"Whether perturbations of any of these endosome-related processes can give rise to TLR7 gain-of-function and facilitate self-reactivity has not been investigated. Here, we show that a dysregulated endosomal compartment leads to unrestricted TLR7 signaling and human lupus."

#Preprint #Immunology #InnateImmunity #Lupus #TollLikeReceptor

https://www.biorxiv.org/content/10.1101/2023.04.03.535356v1

"Whether perturbations of any of these endosome-related processes can give rise to TLR7 gain-of-function and facilitate self-reactivity has not been investigated. Here, we show that a dysregulated endosomal compartment leads to unrestricted TLR7 signaling and human lupus."

#Preprint #Immunology #InnateImmunity #Lupus #TollLikeReceptor

https://www.biorxiv.org/content/10.1101/2023.04.03.535421v1

"Here, we investigate a β-cyclodextrin nanoparticle (CDNP) formulation encapsulating the Toll-like receptor 7 and 8 (TLR7/8) agonist R848 (CDNP-R848) to reprogram myeloid cells in the glioma microenvironment."

#immunology #TollLikeReceptor #InnateImmunity #Immunotherapy

https://www.nature.com/articles/s41467-023-36321-6