Lilly walks away from Nektar's PEG conjugate of rhIL-2, rezpeg - aka rezpegaldesleukin, aka NKTR-358 - after disappointing phase II results in lupus.

#Immunology #immunotherapy #RegulatoryTCell #Lupus #Treg #drugdevelopment

https://www.fiercebiotech.com/biotech/after-gathering-enough-nektar-lilly-hands-backs-rights-immunology-med-post-lupus-fail

"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."

#immunology #Treg

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183

Review at EJI

"Dysregulation or overproduction of IL-6 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL-6 in altering the balance between Treg and Th17 cells, controlling IL-6 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases."

#Immunology #Treg #Th17 #Autoimmunity

https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201040391

"These results identify a Notch1/CD22 signaling axis that disrupts Treg function in MIS-C and point to distinct immune checkpoints controlled by individual Treg Notch receptors that shape the inflammatory outcome in SARS-CoV-2 infection."

#COVID #COVID19 #MISC #TREG #notch

https://www.jci.org/articles/view/163235

I like this intro jump from Mitchison to Sakaguchi (ref 21 to 22)

"Forty years ago, high-zone immune tolerance had been suggested to be mediated by suppressor T cells (21). The existence of suppressor T cells has long remained controversial and was not accepted until regulatory T cells (Tregs) were characterized more than 15 years later (22)."

#Immunology #Tolerance #Treg #Hemophilia