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The EMBO Journal · @embojournal
548 followers · 284 posts · Server sciencemastodon.com
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Global histone H2B degradation regulates /#IGF signaling-mediated nutrient stress

The - system regulates exchange in mammalian cells and in C. elegans during development and starvation.

embopress.org/doi/full/10.1525

#insulin #Ubiquitin #proteasome #histone #h2b

Last updated 1 year ago
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The EMBO Journal · @embojournal
534 followers · 266 posts · Server sciencemastodon.com
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What can bacteria teach us about unexplored areas of signaling and regulation?
John Pruneda and colleagues discuss how subvert the host cell system by either adopting or breaking its rules
New review article as !

embopress.org/doi/full/10.1525

#Ubiquitin #pathogens #ubiquitination #weekendreading

Last updated 1 year ago
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The EMBO Journal · @embojournal
461 followers · 225 posts · Server sciencemastodon.com
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NRON promotes by regulating /#MDMX heterodimerization and enhancing their -dependent degradation of multiple proteins
Erwei Song, Man-Li Luo and coworkers
embopress.org/doi/full/10.1525

#lncrna #tumorigenesis #mdm2 #Ubiquitin #tumorsuppressor

Last updated 1 year ago
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The EMBO Journal · @embojournal
460 followers · 219 posts · Server sciencemastodon.com
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Are there functions specific to and -based E3 ?

Matthias Peter Lab, Anna Stier et al find a CUL4B-specific N-terminal extension undergoing heavy , and promoting recruitment of a specific set of substrate receptors involved in regulation

embopress.org/doi/10.15252/emb

#cul4a #cul4b #Ubiquitin #ligases #mitotic #phosphorylation #dcaf #cytoskeleton

Last updated 1 year ago
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The EMBO Journal · @embojournal
452 followers · 204 posts · Server sciencemastodon.com
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Chloroplast protein import is controlled not just by the - system, but also by selective -mediated selective of translocon components in upon UV light or heat stress
embopress.org/doi/10.15252/emb

#Ubiquitin #proteasome #nbr1 #autophagy #arabidopsis

Last updated 1 year ago
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The EMBO Journal · @embojournal
441 followers · 175 posts · Server sciencemastodon.com
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Termination of STING responses is mediated via - and -dependent degradation to prevent unwarranted
Katherine Balka, Dominic De Nardo et al @monashuni
embopress.org/doi/10.15252/emb

#escrt #Ubiquitin #inflammation

Last updated 1 year ago
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The EMBO Journal · @embojournal
441 followers · 172 posts · Server sciencemastodon.com
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What controls basal, -independent ?

E3 screen by Sylvie Urbé, Michael Clague and coworkers identifies and as negative regulators of mitophagy receptors and via transcriptional and direct post-translational mechanisms, respectively

embopress.org/doi/10.15252/emb

#parkin #mitophagy #Ubiquitin #ligase #vhl #fbxl4 #nix #bnip3

Last updated 1 year ago
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JIPB · @JIPB
35 followers · 131 posts · Server mstdn.science
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One root, two root, short root, long root! Root toot!
Ma et al. report that The F-box protein SHORT PRIMARY ROOT in modulates primary activity by targeting SEUSS-LIKE protein for degradation.
doi.org/10.1111/jipb.13492
@wileyplantsci

#rice #root #meristem #JIPB #plantscience #DevBio #Ubiquitin

Last updated 1 year ago
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The EMBO Journal · @embojournal
419 followers · 122 posts · Server sciencemastodon.com
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How do FBXL4 mutations lead to depletion syndrome 13?

Hui Jiang et al find increased loss and perinatal lethality in Fbxl4 KO mice due to increased levels of receptors and NIX targeted by SCF- ligase

embopress.org/doi/10.15252/emb

#encephalomyopathic #mtdna #mitochondrial #mitophagy #bnip3 #fbxl4 #Ubiquitin

Last updated 1 year ago
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Benedikt Mandl · @mandl
115 followers · 206 posts · Server mstdn.science
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RT @SFB_TPDvienna
The &Friends Symposium is approaching! Join us in Vienna on 27-28 April. Outstanding line-up of speakers👇
Register & submit your abstract by 30 March to apply for a selected talk.
Space is limited! So register now to save your spot:
protein-degradation.org/sympos

#Ubiquitin

Last updated 1 year ago
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IMP · @IMPvienna
511 followers · 160 posts · Server mstdn.science
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RT @SFB_TPDvienna
The &Friends Symposium is approaching! Join us in Vienna on 27-28 April. Outstanding line-up of speakers👇
Register & submit your abstract by 30 March to apply for a selected talk.
Space is limited! So register now to save your spot:
protein-degradation.org/sympos

#Ubiquitin

Last updated 1 year ago
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Andrea Pauli · @PauliGroup
163 followers · 128 posts · Server mstdn.science
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RT @SFB_TPDvienna
The &Friends Symposium is approaching! Join us in Vienna on 27-28 April. Outstanding line-up of speakers👇
Register & submit your abstract by 30 March to apply for a selected talk.
Space is limited! So register now to save your spot:
protein-degradation.org/sympos

#Ubiquitin

Last updated 1 year ago
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The EMBO Journal · @embojournal
411 followers · 102 posts · Server sciencemastodon.com
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EMBO Journal Issue 4/23:
- Commentary on needs in research
- recognition in orphan complex subunits by CLR4-DCAF12 E3
- topography of receptors
- roles and regulation in
- interplay with severing

Cover by Satarupa Bhaduri, Analine Aguayo, Sonya Neal et al
embopress.org/toc/14602075/202

#creativity #degron #Ubiquitin #ligase #plasmamembrane #IgM #Bcell #yap #tumorigenesis #brassinosteroid #katanin #microtubule

Last updated 1 year ago
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The EMBO Journal · @embojournal
411 followers · 98 posts · Server sciencemastodon.com
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Viral mimicry of a adaptor: shows how rodent E27/M27 hijacks host cell -RING E3s to degrade and suppress signaling
embopress.org/doi/10.15252/emb

#dcaf #Ubiquitin #ligase #cryoem #cytomegalovirus #cmv #crl4 #cullin #stat2 #Antiviral #interferon

Last updated 1 year ago
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CellBioNews · @cellbionews
25 followers · 537 posts · Server scientificnetwork.de

#endoplasmic #protein #rice #agriculture #Ubiquitin #proteasome

Last updated 1 year ago
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CellBioNews · @cellbionews
25 followers · 505 posts · Server scientificnetwork.de

#pub8 #seedling #growth #arabidopsis #signalling #hormones #abi3 #Ubiquitin

Last updated 2 years ago
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The EMBO Journal · @embojournal
403 followers · 85 posts · Server sciencemastodon.com
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Protein complex assembly in action:
structures by Nico Thomä at FMI and colleagues show how - E3 engages a C-terminal di-Glu in CCT5 recognizable only when this subunit is not incorporated into the /#CCT complex
embopress.org/doi/10.15252/emb

#qualitycontrol #cryoem #crl4 #dcaf12 #Ubiquitin #ligase #degron #tric #chaperone

Last updated 2 years ago
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The EMBO Journal · @embojournal
403 followers · 84 posts · Server sciencemastodon.com
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In EMBO Journal issue 3:

Host negotiate peace with
Cytosolic relieve nuclear - system
and ER exit links in signaling
Developmental decision control by reader
Cover by Kimon Lemonides, Helen Walden et al

embopress.org/toc/14602075/202

#mucins #toxigenic #vibrio #StressGranules #Ubiquitin #proteasome #smoothened #cholesterylation #hedgehog #cellfate #chromatin #trim33

Last updated 2 years ago
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The EMBO Journal · @embojournal
371 followers · 64 posts · Server sciencemastodon.com
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What happens to the - system in cells that cannot form ?
Nico Dantuma & coworkers at Karolinska Institute find surprising relocalization of DRiP , compromising in the nucleus
embopress.org/doi/10.15252/emb

#Ubiquitin #proteasome #StressGranules #nucleolar #peptides #proteostasis

Last updated 2 years ago
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Journal of Cell Science · @J_Cell_Sci
598 followers · 91 posts · Server mstdn.science
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The final 'First person' interview in our current Issue is with Vaishna Vamadevan on her PhD project in Subbareddy Maddika's lab at Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, India, investigating the role of ubiquitylation in regulating various cellular events:
journals.biologists.com/jcs/ar

#cellbiology #research #Ubiquitin #phaseseparation #Science #sciencemastodon #EarlyCareerResearcher

Last updated 2 years ago
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