#Sirt6 #VascularInflammation

MRTF-A as a deacetylation target of Sirt6 in #EndothelialCell

Deactylated MRTF-A stays in cytoplasm, failing to mediate oxLDL-induced EC ICAM1

An OxLDL-DNMT1 cacade epigenetically silences Sirt6 expression

Dr. Qianyun Wang, Tianfa Li & Qianwen Zhao labs Cell Death Discov 2022
https://www.nature.com/articles/s41420-022-00903-y